摘要
目的:探讨阿托伐他汀钙联合丁苯酞序贯疗法治疗急性缺血性脑血管病(AICD)的效果及对认知行为学、神经影像学的影响。方法:选取2018年12月-2021年12月于赣州市立医院就诊的AICD患者80例,按照随机数字表法将患者分为观察组(n=40)和对照组(n=40)。常规治疗基础上,对照组采取丁苯酞序贯疗法,观察组采取阿托伐他汀钙联合丁苯酞序贯疗法。比较两组疗效、不良反应、神经功能缺损评分(NIHSS)、改良Rankin量表(mRS)评分、简易精神状态量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、神经影像学指标[梗死灶体积、相对表观扩散系数值(rADC)]、炎症反应相关指标[白细胞计数、中性粒细胞比率、C反应蛋白(CRP)]水平。结果:观察组总有效率92.50%高于对照组75.00%(P<0.05)。治疗后,观察组NIHSS评分、mRS评分均低于对照组(P<0.05)。治疗后,观察组MMSE评分、MoCA评分均高于对照组(P<0.05)。治疗后,观察组梗死灶体积小于对照组,rADC高于对照组(P<0.05)。治疗后两组白细胞计数、中性粒细胞比率、CRP水平均低于治疗前,且观察组均低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿托伐他汀钙联合丁苯酞序贯疗法治疗AICD患者,可减轻炎症反应,改善神经功能与认知功能,疗效显著,安全性高。
Objective:To investigate the effect of Atorvastatin Calcium with Butylphthalide sequential therapy in the treatment of acute ischemic cerebrovascular disease(AICD) and its influence on cognitive behavior and neuroimaging.Method:A total of 80 AICD patients who were treated in Ganzhou Municipal Hospital from December 2018 to December 2021 were selected,they were randomly divided into observation group(n=40)and control group(n=40) according to random number table method.On the basis of conventional treatment,the control group received Butylphthalide sequential therapy,and the observation group received Atorvastatin Calcium combined with Butylphthalide sequential therapy.The efficacy,adverse reactions,neurological deficit scores(NIHSS),modified Rankin scale(mRS),mini-mental state scale(MMSE),Montreal cognitive assessment(MoCA),neuroimaging indicators [infarct volume,relative apparent diffusion coefficient(rADC)] and inflammatory responserelated indicators [white blood cell count,neutrophil ratio,C reactive protein(CRP)] were compared between the two groups.Result:The total effective rate of the observation group was 92.50%,which was higher than 75.00% of the control group(P<0.05).After treatment,the NIHSS scores and mRS scores of the observation group were lower than those of the control group(P<0.05).After treatment,the MMSE scores and MoCA scores of the observation group were higher than those of the control group(P<0.05).After treatment,the infarct volume of the observation group was smaller than that of the control group,and the rADC of the observation group was higher than that of the control group(P<0.05).After treatment,the white blood cell count,neutrophil ratio and CRP level of both groups were lower than those before treatment,those of the observation group were lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Atorvastatin Calcium combined with Butylphthalide sequential therapy in the treatment of AICD patients can reduce inflammation and improve neurological and cognitive functions,with significant curative effect and high safety.
作者
廖益
LIAO Yi(Ganzhou Municipal Hospital,Jiangxi Province,Ganzhou 341000,China)
出处
《中国医学创新》
CAS
2022年第36期24-28,共5页
Medical Innovation of China
关键词
阿托伐他汀钙
丁苯酞
序贯疗法
急性缺血性脑血管病
认知行为学
神经影像学
Atorvastatin Calcium
Butylphthalide
Sequential therapy
Acute ischemic cerebrovascular disease
Cognitive behavior
Neuroimaging
