摘要
目的分析首发精神分裂症(schizophrenia,SP)患者糖脂代谢异常情况。方法选取江门市第三人民医院83例首发精神分裂症患者作为本次研究观察组,时间2021年1~12月,另选取同期83例健康体检者作为本次研究对照组,观察比较两组的糖代谢指标和脂代谢指标,分析首发精神分裂症患者糖脂代谢异常情况。结果观察组的FGLU指标为(4.78±0.58)mmol/L,对照组为(4.72±0.47)mmol/L,两组基本一致(P>0.05);观察组的TG指标、CHOL指标、LDL-C指标和ApoB指标均分别为(1.18±0.38)mmol/L、(4.17±0.93)mmol/L、(2.58±0.81)mmol/L和(0.64±0.24)mmol/L,对照组为(1.13±0.31)mmol/L、(4.13±0.87)mmol/L、(2.53±0.92)mmol/L和(0.61±0.12)mmol/L,两组基本一致(P>0.05);观察组的APOE指标(3.25±0.12)mmol/L、HDL-C指标(1.15±0.10)mmol/L和ApoAⅠ指标(1.07±0.10)mmol/L均明显低于对照组的(3.59±0.13)mmol/L、(1.73±0.42)mmol/L和(1.41±0.28)mmol/L,差异有统计学意义(P<0.05)。结论首发精神分裂症患者存在明显糖脂代谢异常表现,患者的APOE指标、HDL-C指标和ApoAⅠ指标均低于正常人,持续关注上述指标,能够评价患者病情程度和预后效果,便于为患者后续治疗提供重要信息依据。
Objective To analyze the abnormal glucose and lipid metabolism in patients with first-episode schizophrenia(SP).Methods 83 patients with primary schizophrenia were selected as the observation group of this study from January 2021 to December 2021,and 83 patients with health examination in the same period were selected as the control group to compare the glucose metabolism indexes and lipid metabolism indexes of the two groups,and analyze the abnormal glucose and lipid metabolism in patients with primary schizophrenia.Results The FGLU index in the observation group was(4.78±0.58)mmol/L and(4.72±0.47)mmol/L in the control group,and the two groups are basically the same(P>0.05);the TG,CHOL,LDL-C and ApoB indicators in the observation group were(1.18±0.38)mmol/L,(4.17±0.93)mmol/L,(2.58±0.81)mmol/L and(0.64±0.24)mmol/L,respectively,those in the control groups were(1.13±0.31)mmol/L,(4.13±0.87)mmol/L,(2.53±0.92)mmol/L,and(0.61±0.12)mmol/L,and the two groups are basically the same(P>0.05);the APOE(3.25±0.12)mmol/L,HDL-C(1.15±0.10)mmol/L and ApoAI(1.07±0.10)mmol/L of the observatioon group were significantly lower than(3.59±0.13)mmol/L,(1.730.42)mmol/L and(1.41±0.28)mmol/L of the control group,and the difference was significant(P<0.05).Conclusion Patients with first schizophrenia have obvious abnormal glucose and lipid metabolism,and their APOE,HDL-C and ApoAI indexes are all lower than those of normal patients.Continuous attention to the above indicators can evaluate the disease degree and prognostic effect of patients,and provide important information for the subsequent treatment of patients.
作者
陈振健
CHEN Zhenjian(Jiangmen Third People’s Hospital,Jiangmen,Guangdong,529000)
出处
《智慧健康》
2022年第29期62-65,共4页
Smart Healthcare
关键词
首发精神分裂症
糖脂代谢
First-episode of schizophrenia
Glucose and lipid metabolism
