摘要
目的了解北京市健康体检人群队列的甲状腺结节发生情况,并探讨其影响因素。方法采用前瞻性队列研究方法,选取2015—2016年在北京市体检中心参加健康体检,并分别于2017—2018年和2019—2020年完成2次随访调查的18岁以上人群作为研究对象,收集体检(包括身高、体质量、血压、血糖等)和问卷调查(包括活动强度、饮食习惯等)数据,记录调查对象在随访期间的甲状腺结节发生情况,并采用多因素logistic回归分析甲状腺结节发生的影响因素。结果共纳入4907名研究对象,其中男2759人,女2148人,甲状腺结节的发病密度为58.2/1000人年。多因素logistic回归分析显示,女性(OR=1.880,95%CI:1.605~2.205)、年龄40~59岁(OR=1.381,95%CI:1.191~1.601)和≥60岁(OR=1.444,95%CI:1.025~2.030)、吸烟6~20支/d(OR=1.510,95%CI:1.239~1.838)、经常饮用绿茶(OR=1.244,95%CI:1.036~1.492)、每周饮用牛奶3~5次(OR=1.267,95%CI:1.100~1.459)及高血压(OR=1.361,95%CI:1.139~1.625)与甲状腺结节发生呈正相关(P<0.05);饮用咖啡(OR=0.628,95%CI:0.429~0.900)与甲状腺结节发生呈负相关(P<0.05)。结论北京市甲状腺结节发生率处于较高水平,女性、年龄增加、吸烟、饮用绿茶和牛奶及高血压是甲状腺结节发生的危险因素,饮用咖啡是甲状腺结节发生的保护因素。
Objective To investigate the incidence and influencing factors of thyroid nodules in a cohort of health check-up population in Beijing.Methods Health examinees over 18 years old in Beijing from 2015-2016 who finished follow-up in 2017-2018 and 2019-2020,were respectively selected as the research objects in a prospective cohort study method.The data of physical examinations(including height,body weight,blood pressure,blood glucose,etc.)and questionnaires(including activity intensity,dietary habits,etc.)were collected.The incidence of thyroid nodules during the follow-up period was recorded,and the influencing factors of thyroid nodules were analyzed by multivariate logistic regression.Results A total of 4907 subjects were included,including 2759 males and 2148 females.The incidence density of thyroid nodules was 58.2/1000 person-years.Multivariate logistic regression analysis showed that female(OR=1.880,95%CI:1.605-2.205),age 40-59 years old(OR=1.381,95%CI:1.191-1.601)and≥60 years old(OR=1.444,95%CI:1.025-2.030),smoking 6-20 cigarettes/day(OR=1.510,95%CI:1.239-1.838),drinking green tea regularly(OR=1.244,95%CI:1.036-1.492),drinking milk 3-5 times per week(OR=1.267,95%CI:1.100-1.459)and hypertension(OR=1.361,95%CI:1.139-1.625)were positively correlated with the occurrence of thyroid nodule(P<0.05).Regular coffee consumption(OR=0.628,95%CI:0.429-0.900)was negatively correlated with the thyroid nodule occurrence(P<0.05).Conclusions The incidence of thyroid nodule in Beijing is at a high level.Female,increasing age,smoking,drinking green tea and milk and hypertension are the risk factors of thyroid nodule,and drinking coffee is a protective factor for the development of thyroid nodules.
作者
陈硕
张静波
于思琪
刘相佟
孔邻润
陶丽新
郭秀花
Chen Shuo;Zhang Jingbo;Yu Siqi;Liu Xiangtong;Kong Linrun;Tao Lixin;Guo Xiuhua(Beijing Key Laboratory of Clinical Epidemiology,School of Public Health,Capital Medical University,Beijing 100069,China)
出处
《北京医学》
CAS
2022年第9期816-822,共7页
Beijing Medical Journal
基金
国家重点研发计划(2020YFC2003400)。
关键词
甲状腺结节
发生
影响因素
队列研究
thyroid nodules
incidence
influencing factors
cohort study
