摘要
目的对3,4,5-三甲氧基肉桂酸(3,4,5-trimethoxy cinnamic acid,TMCA)酯类衍生物的生物活性进行总结。方法查阅相关文献,对TMCA衍生物的活性及构效关系进行综述。结果根据文献报道总结天然产物的TMCA酯类衍生物活性的来源,并且从抗肿瘤、抗病毒、神经系统等方面阐述了合成TMCA酯类化合物的活性。结论通过对TMCA酯类衍生物活性及构效关系进行总结,可为该类药物的深入开发提供依据。
Objective To summarize the biological activities of 3,4,5-trimethoxy cinnamic acid(TMCA)ester derivatives.Methods The activity and structure-activity relationship of TMCA derivatives were reviewed by refering to relative articles.Results The sources of the activity of TMCA ester derivatives of natural products were summarized according to the literature,and the activity of synthetic TMCA ester compounds was expounded from the aspects of anti-tumor,anti-virus and nervous system.Conclusion The review of activity and structure-activity relationship of TMCA derivatives can provide basis for further research and development of valuable precursors.
作者
年梦
赵泽丰
吕红
王晨冉
杨晓航
乔海法
李斌
白育军
吴少平
郑晓晖
NIAN Meng;ZHAO Zefeng;L Hong;WANG Chenran;YANG Xiaohang;QIAO Haifa;LI Bin;BAI Yujun;WU Shaoping;ZHENG Xiaohui(Shaanxi Key Laboratory of Acupuncture&Medicine,Shaanxi University of Chinese Medicine,Xianyang 712046,China;College of Life Science,Northwest University,Xi'an 710069,China)
出处
《西北药学杂志》
CAS
2023年第1期215-221,共7页
Northwest Pharmaceutical Journal
基金
国家自然科学基金项目(编号:8210142829)
陕西省自然科学基础研究项目(编号:2022JQ-823)
陕西省教育厅科研计划项目(编号:21JS020)
陕西中医药大学经脉-脏腑相关研究创新团队项目(编号:YL-09)
陕西中医药大学博士科研启动金项目(编号:303-17102032024)
陕西中医药大学校级科研课题(编号:2021GP01)
陕西省科技厅中医诊疗装备研发相关研究创新团队项目(编号:303-202210705)。
关键词
3
4
5-三甲氧基肉桂酸
生物活性
衍生物
3,4,5-trimethoxy cinnamic acid
biological activities
derivatives
