摘要
目的 探讨妊娠间隔与小于胎龄儿、大于胎龄儿的关系,为再生育妇女提供孕前咨询及公共卫生政策制定提供依据。方法 选取2015-2020年广东省妇幼保健院有连续2次分娩史的7 752名产妇及胎儿数据,根据妊娠间隔将研究对象分为5组(<6、6~11、12~17、18~23、≥24个月),采用logistic回归模型对妊娠间隔与小于胎龄儿、大于胎龄儿的关系进行分析。结果 研究对象中小于胎龄儿发生率为12.40%,大于胎龄儿发生率为4.72%。控制可能的混杂因素后,logistic回归分析结果显示,与妊娠间隔12~17个月相比,妊娠间隔<6个月者,小于胎龄儿的危险性增加(OR=1.42,95%CI=1.14~1.79),妊娠间隔6~11个月发生小于胎龄儿的风险增加(OR=1.36,95%CI=1.13~1.64)。妊娠间隔与大于胎龄儿的关联无统计学意义。结论 妊娠间隔<12个月是小于胎龄儿的独立危险因素,应在产前咨询和健康教育等方面普及适宜的妊娠间隔重要性,以减少短妊娠间隔妊娠;对短时间间隔内再次怀孕的妇女,应该加强监测,减少小于胎龄儿的发生。
Objective To explore the effect of interpregnancy interval on small for gestational age(SGA) and large for gestational age(LGA) birth and to provide evidence to the consultation about multiparous pregnancy and the development of public health policies. Methods Complete information on 7 752 mother-infant pairs of two consecutive delivery from 2015through 2020 were collected from Guangdong Provincial Maternal and Child Health Hospital. The mothers′ interpregnancy intervals were were divided into 5 groups of < 6, 6 – 11, 12 – 17, 18 – 23, ≥ 24 months. Logistic regression model was adopted in the analysis on the association of interpregnancy interval with small/large for gestational age birth. Results For all the mothers aged 26.57 ± 4.03 years at their second childbirth, the incidence of SGA birth was 12.40% and that of LGA birth was 4.72%, respectively. Logistic regression results showed that short interpregnancy interval was significantly associated with SGA birth after adjusting potential confounders. Compared to the mothers with the interpregnancy interval of12 – 17 months, the mothers with shorter interpregnancy intervals had a significantly increased risk of SGA birth, with the odds ratios of 1.42(95% confidence interval: 1.14 – 1.79) for the mothers with the interpregnancy interval of < 6 months and1.36(1.13 – 1.64) for the mothers with the interpregnancy interval of 6 – 11 months. No significant association between interpregnancy interval and LGA birth was observed. Conclusion Interpregnancy interval less than 12 months is an independent risk factor for small for gestational age birth. The optimal interpregnancy interval should be emphasized in prenatal consultation and health education to reduce the risk of adverse birth outcome.
作者
樊高杰
刘晴
陈凯
王璐琳
武丽
王友洁
FAN Gao-jie;LIU Qing;CHEN Kai(Department of Maternal and Child Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei Province 430030,China;不详)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2022年第9期1130-1134,共5页
Chinese Journal of Public Health
基金
国家自然科学基金(82073660)。
关键词
妊娠间隔
小于胎龄儿
大于胎龄儿
不良妊娠结局
interpregnancy interval
small for gestational age
large for gestational age
adverse birth outcome
