摘要
目的观察扶正香囊对反复上呼吸道感染患者免疫功能的影响。方法将符合标准的180例反复上呼吸道感染患者按照1:1的比例随机分为治疗组和对照组,治疗组佩戴扶正香囊,对照组口服玉屏风颗粒,3个月后观察2组患者总有效率、中医证候积分、T细胞亚群CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、B细胞、自然杀伤(NK)细胞和免疫球蛋白IgG、IgM、IgA水平。结果疗程结束后,治疗组总有效率为84.4%,对照组总有效率为87.8%,2组比较差异无统计学意义(P>0.05)。2组患者治疗后中医证候积分均较治疗前降低(P<0.05),2组间同期比较差异无统计学意义(P>0.05)。治疗后2组的T淋巴细胞亚群CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、B细胞、NK细胞和对照组CD8+水平均较治疗前上升(P<0.05),治疗组CD8+较治疗前上升但差异无统计学意义(P>0.05);2组血清免疫球蛋白IgG和IgM均较治疗前上升(P<0.05),对照组IgA也较治疗前上升(P<0.05),治疗组IgA较治疗前有上升趋势,但差异无统计学意义(P>0.05);2组患者上述免疫功能指标同期组间比较均差异无统计学意义。结论扶正香囊能有效改善反复上呼吸道感染患者的症状,并改善患者的免疫功能指标。
Objective To observe the affection of Fuzheng Sachet to the patients′immunity whom had recurrent upper respiratory infection.Methods One hundred and eighty patients with recurrent upper respiratory infection were divided into treatment group and control group according to 1:1 ratio randomly.The treatment group was given Fuzheng sachet to wear,while the control group was given Yupingfeng granules orally.After 3 months,the overall curative effect of the two groups,the score of traditional Chinese medicine syndrome,classification of morbility rate and the levels of T cells subsets CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),B cells,NK cells and immune globulin levels(IgG、IgM、IgA)were observed and recorded.Results The total effective rate of the treatment group was 84.4%while the control group was 87.8%.There was no significant difference between the two groups(P>0.05).The scores of traditional Chinese medicine syndrome of both groups were decreased after the treatment and there was statistically different(P<0.05).However,there was no statistically difference between the two groups(P>0.05).After treatment,the classification of morbility rate in the treatment group and control group decreased and there were statistically significance.The levels of T lymphocyte subsets such as CD3^(+),CD4^(+),CD4^(+)/CD8^(+),B cells,NK cells of the both groups and CD8+of the control group were increased after the treatment.There was statistically difference(P<0.05).Even though,the levels of CD8+of the treatment group increased after the treatment,but there was no statistically difference(P>0.05).The level of IgG and IgM of the both groups and the level of IgA in the control group increased and they were statistically different(P<0.05).The level of IgA in the treatment group increased after the treatment,but there was no significant increase(P>0.05).Conclusion Fuzheng Sachet can improve the score of traditional Chinese medicine syndrome and the morbility rate of patients with recurrent upper respiratory infection effectively. The mechanism may be related to the regulation of immune system.
作者
汪虹伶
张艳萍
徐中菊
赵凌雪
卢阳
Wang Hongling;Zhang Yanping;Xu Zhongju;Zhao Lingxue;Lu Yang(School of Traditional Chinese Medicine,ShanghaiUniversity of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《山西医药杂志》
CAS
2022年第20期2292-2295,共4页
Shanxi Medical Journal
基金
上海市治未病服务产品和技术项目[(2018—2020)-ZWB-1001-CPJS21]
上海市中医药事业发展三年行动计划(2018—2020年)医疗机构治未病服务能力提升项目[ZY(2018—2020)-ZWB-1001]
上海市中医药领军人才培养项目[ZY(2018—2020)-RCPY-1027]
徐中菊名中医工作室建设项目(CNMZY-2021008)
上海市长宁区博士创新基地建设项目(RCJD2021B04)。
