摘要
目的:观察活血化瘀膏治疗气滞血瘀型前部缺血性视神经病变患者的效果。方法:选取2020年7月至2021年8月该院收治的70例气滞血瘀型前部缺血性视神经病变患者进行前瞻性研究,采用随机数字表法将其分为对照组和观察组各35例。对照组给予常规治疗,观察组在对照组基础上给予活血化瘀膏治疗,比较两组临床疗效、治疗前后LogMAR视力水平、视野指标[平均缺损(MD)、平均光敏感度(MS)]水平,眼动脉、睫状后短动脉、视网膜中央动脉血流动力学参数[收缩期峰值流速(PSV)、舒张末期血流速度(EDV)、搏动指数(PI)及阻力指数(RI)]水平,以及治疗期间不良反应发生率。结果:观察组治疗总有效率为94.29%(33/35),高于对照组的68.57%(24/35),差异有统计学意义(P<0.05);治疗2周、30 d和随访2个月后,观察组LogMAR视力、MD水平均低于对照组,MS水平高于对照组,差异有统计学意义(P<0.05);治疗2周、30 d后,观察组眼动脉、睫状后短动脉和视网膜中央动脉PSV、EDV、PI水平均高于对照组,RI水平低于对照组,差异有统计学意义(P<0.05);两组治疗期间均无不良反应发生。结论:在常规治疗基础上采用活血化瘀膏治疗气滞血瘀型前部缺血性视神经病变患者可提高治疗总有效率,改善视野指标水平和眼动脉、睫状后短动脉、视网膜中央动脉血流动力学参数水平,降低LogMAR视力水平,效果优于单纯常规治疗。
Objective:To observe the effect of Huoxue Huayu ointment in treating patients with anterior ischemic optic neuropathy of qi stagnation and blood stasis type.Methods:A prospective study was conducted on 70 patients with anterior ischemic optic neuropathy of qi stagnation and blood stasis type admitted to this hospital from July 2020 to August 2021.They were divided into control group and observation group by using the random number table method,35 cases in each.The control group was given routine treatment,while the observation group was treated with Huoxue Huayu ointment on the basis of that of the control group.The clinical efficacy,LogMAR visual acuity levels before and after the treatment,the visual field index levels[mean defect(MD),mean light sensitivity(MS)],the hemodynamic parameter levels of ophthalmic artery,short posterior ciliary artery,central retinal artery[peak systolic velocity(PSV),end diastolic velocity(EDV),pulsatility index(PI)and resistance index(RI)],and the incidence of adverse reactions during the treatment were compared between the two groups.Results:The total effective rate of treatment in the observation group was 94.29%(33/35),which was higher than 68.57%(24/35)in the control group,and the difference was statistically significant(P<0.05).2 weeks and 30 days after the treatment and at 2 months of follow-up,the LogMAR visual acuity and MD levels in the observation group were lower than those in the control group,the MS level was higher than that in the control group,and the differences were statistically significant(P<0.05).2 weeks and 30 days after the treatment,the PSV,EDV and PI levels of ophthalmic artery,short posterior ciliary artery and central retinal artery in the observation group were higher than those in the control group,the RI level was lower than that in the control group,and the differences were statistically significant(P<0.05).However,no adverse reactions occurred during the treatment in both groups.Conclusions:On the basis of the routine treatment,Huoxue Huayu ointment can improve the total effective rate of treatment,improve the levels of visual field indexes and the hemodynamic parameters of ophthalmic artery,posterior ciliary artery and central retinal artery,and reduce the levels of LogMAR visual acuity in the patients with anterior ischemic optic neuropathy of qi stagnation and blood stasis type.Moreover,it is superior to single routine treatment.
作者
吴小桃
李霭燕
黎灿文
WU Xiaotao;LI Aiyan;LI Canwen(Guangzhou Panyu District Hospital of Traditional Chinese Medicine,Ophthalmology,Guangzhou 511400 Guangdong,China;Guangzhou Panyu District Hospital of Traditional Chinese Medicine,Pharmacy Department,Guangzhou 511400 Guangdong,China;Guangzhou Panyu District Hospital of Traditional Chinese Medicine,Department of Clinical Laboratory,Guangzhou 511400 Guangdong,China)
出处
《中国民康医学》
2022年第23期106-109,共4页
Medical Journal of Chinese People’s Health
基金
番禺区科技计划项目(2019-Z04-72)。
关键词
前部缺血性视神经病变
气滞血瘀型
活血化瘀膏
视力
视野
血流动力学
不良反应
Anterior ischemic optic neuropathy
Qi stagnation and blood stasis type
Huoxue Huayu ointment
Visual acuity
Visual Field
Hemodynamics
Adverse reaction
