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住院2型糖尿病患者胰岛素泵降糖后不同治疗方案日内血糖变异情况比较 被引量:5

Comparison of the intra-day blood glucose variation indexes of inpatients with type 2 diabetes mellitus between different treatment regimens after insulin pump treatment
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摘要 目的探讨住院2型糖尿病患者经皮下胰岛素泵降糖后给予不同治疗方案日内血糖变异情况。方法选取2型糖尿病患者165例,均给予皮下胰岛素泵强化降糖,血糖达标后给予撤泵,随机分为地特+门冬胰岛素组(对照组)和门冬胰岛素30注射液组(试验组)。比较2组撤泵当日的血糖变异指标:撤泵当日最小血糖值(minimum blood glucose before removing the subcutaneous pump,bminGlu)、撤泵当日血糖水平的标准差(standard deviation of blood glucose before removing the subcutaneous pump,bSDBG)、撤泵当日餐后血糖波动幅度(postprandial glucoseexcursion before removing the subcutaneous pump,bPPGE)、撤泵当日最大血糖波动幅度(largest amplitudeof glycemic excursions before removing the subcutaneous pump,bLAGE)、撤泵当日胰岛素总量(total insulin before removing the subcutaneous pump,bTins)。比较2组皮下注射胰岛素后第4天的血糖变异指标:皮下注射胰岛素后第4天最小血糖值(minimum blood glucose after removing the subcutaneous pump,aminGlu)、皮下注射胰岛素后第4天血糖水平的标准差(standard deviation of blood glucose after removing the subcutaneous pump,aSDBG)、皮下注射胰岛素后第4天餐后血糖波动幅度(postprandial glucoseexcursion after removing the subcutaneous pump,aPPGE)、皮下注射胰岛素后第4天最大血糖波动幅度(largest amplitudeof glycemic excursions after removing the subcutaneous pump,aLAGE)、皮下注射胰岛素后第4天胰岛素总量(total insulin after removing the subcutaneous pump,aTins)。结果2组患者bminGlu、bSDBG、bPPGE、bLAGE、bTins、aminGlu、aSDBG、aPPGE、aLAGE、aTins差异均无统计学意义(P>0.05)。结论住院2型糖尿病患者使用皮下胰岛素泵强化降糖后更换为门冬胰岛素30注射液2次/d与餐时门冬胰岛素+地特胰岛素注射液均能较好的控制血糖、减少血糖波动。 Objective To study the intra-day blood glucose variation of inpatients with type 2 diabetes mellitus(T2DM)between different regimens after insulin pump treatment.Methods A total of 165 patients with T2DM were selected and given hypodermic insulin pump for hypoglycemic treatment.The pump was withdrawn after the blood glucose reached the standard.The patients were randomly divided into the detemir(Det)+aspart(Asp)group(control group)and the Asp30 group(experimental group).Blood glucose variation indexes including minimum blood glucose before removing the subcutaneous pump(bminGlu),standard deviation of blood glucose before removing the subcutaneous pump(bSDBG),postprandial glucose excursion before removing the subcutaneous pump(bPPGE),largest amplitude of glycemic excursions before removing the subcutaneous pump(bLAGE)and total insulin before removing the subcutaneous pump(bTins)on the day of pump with drawal were compared between two groups.The blood glucose variation indexes on the 4th day after insulin injection were compared between two groups,including minimum blood glucose after removing the subcutaneous pump(aminGlu),standard deviation of blood glucose after removing the subcutaneous pump(aSDBG),postprandial glucose excursion after removing the subcutaneous pump(aPPGE),largest amplitude of glycemic excursions after removing the subcutaneous pump(aLAGE)and total insulin after removing the subcutaneous pump(aTins).Results There was no significant difference in bminGlu,bSDBG,bPPGE,bLAGE,bTins,aminGlu,aSDBG,aPPGE,aLAGE and aTins(P>0.05).Conclusion For hospitalized patients with T2DM,both Asp30 injection twice a day and Asp+Det injection at meals could control blood glucose and reduce blood glucose fluctuation after insulin pump treatment.
作者 刘晴晴 付永奇 荣义华 郑坤杰 孙殿静 LIU Qing-qing;FU Yong-qi;RONG Yi-hua;ZHENG Kun-jie;SUN Dian-jing(Department of Endocrinology,Hengshui Harrison International Peace Hospital,Hebei Province,Hengshui 053000,China)
出处 《河北医科大学学报》 CAS 2023年第1期20-24,80,共6页 Journal of Hebei Medical University
基金 河北省医学科学研究课题计划(20200184)。
关键词 糖尿病 2型 地特胰岛素 门冬胰岛素 diabetes mellitus,type 2 insulin detemir insulin aspart
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