摘要
目的探讨醋酸曲普瑞林联合坤泰胶囊治疗子宫内膜异位症(EMT)的效果及对辅助性T淋巴细胞1(Th1)/辅助性T淋巴细胞2(Th2)漂移的影响。方法选取2018年8月至2020年6月新郑市公立人民医院妇产科收治的74例EMT患者,根据随机数表法分为对照组与观察组,各37例。两组均接受EMT病灶切除术,对照组接受醋酸曲普瑞林治疗,观察组在对照组基础上接受坤泰胶囊口服治疗。两组均治疗3个疗程。观察两组手术前及治疗后卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E_(2))、干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)及糖类抗原125(CA125)水平;采用多普勒超声检测两组患者治疗前后子宫大小、子宫内膜厚度;比较两组患者总有效率及不良反应发生率。结果与手术前比较,两组患者治疗后血清IL-4水平降低(P<0.05),FSH、LH、E_(2)、IFN-γ水平及IFN-γ/IL-4升高(P<0.05),子宫体积、子宫内膜厚度、CA125水平差异无统计学意义(P>0.05);与对照组比较,观察组治疗后血清FSH、LH、E_(2)及IL-4水平降低(P<0.05),IFN-γ水平及IFN-γ/IL-4升高(P<0.05);两组临床疗效及总有效率比较差异无统计学意义(P>0.05);观察组不良反应发生率低于对照组(P<0.05)。结论醋酸曲普瑞林联合坤泰胶囊治疗EMT可改善患者性激素水平并纠正Th1/Th2漂移,降低不良反应发生率。
Objective To investigate the effect of triptorelin acetate combined with Kuntai capsule in the treatment of endometriosis(EMT)and its influence on the ratio of heper T lymphocyte 1(Th1)to heper T lymphocyte 2(Th2)drift.Methods From August 2018 to June 2020,the patients were randomly divided into control group and observation group by random number table method,with 37 cases in each group.Both groups received EMT lesion resection,the control group was given triptorelin acetate,and the observation group was given Kuntai capsule on the basis of the control group,both groups were treated for 3 courses.The changes of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),interferon-γ(IFN-γ),interleukin-4(IL-4)and carbohydrate antigen 125(CA125)levels were compared before and after treatment between the two groups.The uterine size and endometrial thickness of the two groups were detected by Doppler ultrasound before and after treatment.The total effective rate and incidence of adverse reactions were compared between the two groups.Results Compared with those before operation,the levels of serum IL-4 were decreased(P<0.05),the levels of FSH,LH,E_(2),IFN-γand IFN-γ/IL-4 were increased(P<0.05),while the uterine volume,endometrial thickness and CA125 level had no statistical differences(P>0.05).Compared with the control group,the levels of serum IL-4 in the observation group were decreased(P<0.05),the levels of FSH,LH,E_(2),IFN-γand IFN-γ/IL-4 were increased(P<0.05),and there was no sistatistical difference in clinical efficacy and total effective rate between the two groups(P>0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Triptorelin acetate combined with Kuntai capsule can improve the sex hormone level of EMT patients,correct Th1/Th2 drift and reduce the incidence of adverse reactions.
作者
毕玉洁
张丽娜
BI Yujie;ZHANG Lina(Department of Obstetrics and Gynecology,Xinzheng Public People’s Hospital,Zhengzhou 451100,China)
出处
《河南医学研究》
CAS
2022年第24期4549-4552,共4页
Henan Medical Research
