摘要
目的观察急性后循环脑梗死患者采用氯吡格雷及阿加曲班的疗效及神经功能改善效果。方法选取吉林市化工医院2019年5月—2021年11月确诊并收治的124例急性后循环脑梗死患者,以随机数表法分为观察组(氯吡格雷口服干预+阿加曲班静脉泵注治疗)和对照组(单纯给予氯吡格雷口服干预),每组62例。观察两组疗效、治疗前后的临床指标、不良反应情况。结果观察组总有效率(85.48%)显著高于对照组(62.90%),差异有统计学意义(χ^(2)=8.255,P<0.05)。两组治疗前NIHSS评分及BI指数对比,差异无统计学意义(P>0.05);治疗后两组NIHSS评分及BI指数都较治疗前显著改善,且观察组与对照组相比改善幅度更大,差异有统计学意义(P<0.05)。观察组T1时段TT、PT、APTT显著高于对照组,差异有统计学意义(P<0.05)。结论急性后循环脑梗死患者采用氯吡格雷及阿加曲班联合治疗的疗效确切,可在不紊乱正常凝血功能的前提下显著遏制患者体内的异常高凝状态,改善患者的神经功能及生活能力,安全性高。
Objective To observe the efficacy and neurological function improvement of acute posterior circulation cerebral infarction using clopidogrel and argatroban.Methods A total of 124 patients with acute posterior circulation cerebral infarction diagnosed and admitted to Jilin Chemical Hospital from May 2019 to November 2021 were Setected.The patients were divided into observation group(clopidogrel oral intervention+augatroban intravenous pump treatment)and control group(clopidogrel oral intervention alone)by random number table method,62 cases in each group.The efficacy,clinical indexes before and after treatment,and adverse reactions of the two groups were observed.Results The total effective rate of the observation group was 85.48%,which was significantly higher than that of the control group 62.90%,and the difference was statistically significant(χ^(2)=8.255,P<0.05).There was no statistically significant difference between the NIHSS score and BI indexes before treatment in both groups(P>0.05);after treatment the NIHSS score and BI indexes indexes improved significantly in both groups compared with those before treatment,and the improvement was greater in the observation group compared with the control group,and the difference was statistically significant(P<0.05).TT,PT and APTT at the T1 time period in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The combined treatment of clopidogrel and argatroban in patients with acute posterior circulation cerebral infarction has a definite effect.It can significantly curb the abnormal hypercoagulability in patients without disturbing the normal coagulation function,improve the neurological function and living ability of patients,with high safety.
作者
冷静
孙启东
王孝佳
董阳
韩丽丽
陈芳
LENG Jing;SUN Qidong;WANG Xiaojia;DONG Yang;HAN Lili;CHEN Fang(Department of Neurology,Ward 1,Jilin Chemical Hospital,Jilin,Jilin Province,132021 China;Panzhihua Central Hospital,Panzhihua,Sichuan Province,617000 China)
出处
《系统医学》
2022年第19期111-114,共4页
Systems Medicine
基金
四川省卫生厅科研基金资助项目(140041)。
关键词
急性后循环脑梗死
氯吡格雷
阿加曲班
神经功能
凝血功能
Acute posterior circulation cerebral infarction
Clopidogrel
Argatroban
Neurological function
Coagulation function
