摘要
目的:观察银杏二萜内酯葡胺联合西药治疗脑梗死患者的效果。方法:选取2019年6月至2021年6月该院收治的98例脑梗死患者进行前瞻性研究,按照随机数字表法分为对照组和观察组各49例。对照组给予常规西药治疗,观察组在对照组基础上联合银杏二萜内酯葡胺注射液治疗。比较两组临床疗效,治疗前及治疗7 d后血清超敏C反应蛋白(hs-CRP)水平、神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]评分和凝血纤溶指标[D-二聚体(D-D)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(Fib)]水平。结果:治疗后,两组NIHSS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为95.92%,明显高于对照组的77.55%,差异有统计学意义(P<0.05);治疗后,两组PT、APTT均长于治疗前,且观察组长于对照组,两组D-D、Fib、hs-CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:银杏二萜内酯葡胺联合西药治疗脑梗死患者可提高治疗总有效率,降低NIHSS评分和hs-CRP水平,改善凝血纤溶指标水平,优于常规西药治疗效果。
Objective:To observe effects of Ginkgo diterpene lactone meglumine injection on cerebral infarction.Methods:A prospective study was conducted on 98 patients with cerebral infarction admitted to the hospital from June 2019 to June 2021.They were divided into control group and observation group according to the random number table method,49 cases in each.The control group was given conventional Western medicine treatment,while the observation group was treated with Ginkgo diterpene lactone meglumine injection on the basis of that of the control group.The clinical efficacy,the serum high-sensitivity C-reactive protein(hs-CRP)level,the neurological deficit score[national institutes of health stroke scale(NIHSS)]score,and the blood coagulation fibrinolysis index levels[D-dimer(D-D),activated partial thromboplastin time(APTT),prothrombin time(PT),fibrinogen(Fib)]were compared between the two groups before and 7 days after the treatment.Results:After the treatment,the NIHSS scores of the two groups were lower than those before the treatment,that of the observation group was lower than that of the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 95.92%,which was significantly higher than 77.55%in the control group,and the difference was statistically significant(P<0.05).Further,after the treatment,the PT and APTT in the two groups were longer than those before the treatment,and those in the observation group were longer than the control group;the levels of D-D,Fib and hs-CRP in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:Ginkgo diterpene lactone meglumine combined with conventional western medicine in the treatment of the patients with cerebral infarction can improve the total effective rate,reduce the NIHSS scores and the hs-CRP levels,and improve the levels of blood coagulation and fibrinolysis indexes.Moreover,it is superior to conventional western medicine treatment.
作者
陈雪
CHEN Xue(1^(st)Department of Neurology of Panjin Central Hospital,Panjin 121010 Liaoning,China)
出处
《中国民康医学》
2022年第24期58-60,共3页
Medical Journal of Chinese People’s Health
关键词
脑梗死
阿替普酶
银杏二萜内酯葡胺注射液
神经功能缺损
凝血纤溶
超敏C反应蛋白
Cerebral infarction
Alteplase
Ginkgo diterpene lactone meglumine injection
Neurological deficit
Blood coagulation fibrinolysis
High-sensitivity C-reactive protein
