摘要
目的 回顾性分析血栓弹力图(TEG)在临床使用冷沉淀时的指导意义及效果。方法 收集2018年1月~2021年12月期间本院收治的纤维蛋白原减少症患者289例次,按指导策略将其分为对照组(以凝血检查及临床表现作为输注指标),观察组(除了凝血检查及临床表现外还检测TEG作为输注指标),通过检测观察组输血前后TEG指标和2组患者输血前后的纤维蛋白原(Fg)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT),比较2组患者间,不同血液制品的输注量和使用冷沉淀后的疗效及预后差别。结果 观察组患者的冷沉淀输注效果更佳[(输血后Fg指标(1.92±0.92)vs(1.80±1.00) g/L](P<0.05);在不同血液制品的输注量上也少于对照组,其中红细胞[(1.93±2.69)vs(2.81±3.25) U](P<0.05);新鲜冰冻血浆[(667±378)vs(879±455) mL](P<0.05)。在住院时间上2组无差异,但是观察组的好转率则明显高于对照组。结论 将TEG检测技术应用于指导临床输注冷沉淀中,能使临床用血更加科学合理,从而达到节省血液及改善预后的目的,因而有着较好的临床应用价值。
Objective To retrospectively analyze the guiding significance and effect of thromboelogram(TEG) in the clinical use of cryoprecipitation. Methods A total of 289 patients with fibrinogen reduction, admitted to our hospital between January 2018 and December 2021, were collected. They was divided into control group(using coagulation examination and clinical feature as the transfusion criteria) and observation group(above parameters plus TEG). The TEG index in the observation group before and after transfusion and Fg, APTT, PT, and TT in 2 groups of patients before and after transfusion were monitored. The efficacy and prognosis of different blood products and cryoprecipitate were compared between 2 groups of patients.)Results The efficacy of choprecipitate transfusion was better in the observation group than the control[Fg index after transfusion(g/L) 1.92±0.92 vs 1.80±1.00, P<0.05].And less blood products were used in observation group as compared with the control[ RBC(U) 1.93±2.69 vs 2.81±3.25(P<0.05);FFP(mL) 667±378 vs 879±455(P<0.05)].No differences were noticed by hospital stay between the two groups, but the prognosis in the observed group was significantly better than that in the control. Conclusion It’s scientific and reasonable to apply TEG to guide the clinical transfusion of cryoprecipitate, so as to save blood resources and improve the prognosis.
作者
黄家福
陈梅红
吴耀建
HHUUANG Jiafu;CHEN Meihong;WU Yaojian(Department of Blood Transfusion,the 910 hospital,Quanhou 362000,China)
出处
《中国输血杂志》
CAS
2022年第11期1135-1138,共4页
Chinese Journal of Blood Transfusion
基金
泉州市科技计划项目(项目编号2018N126S)。
