摘要
目的:观察保肾合剂对慢性肾脏病3—5期非透析患者肾功能及营养指标的影响。方法:97例慢性肾脏病3—5期非透析患者随机分为治疗组与对照组。对照组给予常规西医治疗(包括饮食控制及药物治疗),治疗组在对照组治疗基础上给予保肾合剂,两组疗程均为14 d。比较两组患者尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)、肾小球滤过率(estimated glomerularfiltration rate,eGFR)、胱抑素C(cystatin C,Cys C)、血尿酸(uric acid,UA)、白蛋白(albumin,ALB)、血红蛋白(hemoglobin,Hb)等水平,中医证候积分及临床疗效。结果:①两组患者BUN、Scr、Cys C、UA水平均显著低于本组治疗前,eGFR水平显著高于治疗前;治疗组治疗后Scr水平为(248.32±138.63)μmol·L^(-1)、Cys C水平为(2.64±0.98)mg·L^(-1)、UA水平为(368.97±89.82)μmol·L^(-1),三者均低于同期对照组,eGFR为(27.17±15.45)mL·min^(-1)·1.73 m^(-2),高于同期对照组(P<0.05)。②治疗后,两组患者的ALB、Hb水平均高于治疗前,治疗组ALB水平为(39.85±3.19)mg·L^(-1)、Hb水平为(107.73±17.84)g·L^(-1),均高于同期对照组(P<0.05)。③治疗后,治疗组中医证候积分显著低于治疗前,且显著低于同期对照组(P<0.05);治疗组的中医证候有效率(58.0%)及临床有效率(82.0%)均高于对照组(36.2%、55.3%)(P<0.05)。结论:保肾合剂能有效改善患者的肾功能和营养状况,延缓肾脏病进展,缓解临床症状。
Objective:To observe the effect of Baoshen Mixture on renal function and nutritional indexes of non-dialysis patients with chronic kidney disease of 3-5 stages.Methods:97 non dialysis patients with chronic kidney disease of stage 3-5 were randomly divided into treatment group and control group.The control group was treated with conventional western medicine(including diet control and drug treatment),and the treatment group was treated with Baoshen Mixture on the basis of the control group.The course of treatment of both groups was 14 days.The levels of blood urea nitrogen(BUN),serum creatinine(Scr),estimated glomerular filtration rate(eGFR),cystatin C(Cys C),uric acid(UA),albumin(ALB),hemoglobin(Hb),TCM syndrome score and clinical efficacy were compared between the two groups.Results:①The levels of BUN,Scr,Cys C and UA in the two groups were significantly lower than those before treatment,and the levels of eGFR were significantly higher than those before treatment;After treatment,the Scr level in the treatment group was(248.32±138.63)μmol·L^(-1),Cys C level was(2.64±0.98)mg·L^(-1),and UA level was(368.97±89.82)μmol·L^(-1),which were lower than those in the control group at the same period,and eGFR was(27.17±15.45)mL·min^(-1)·1.73 m^(-2),which was higher than that in the control group at the same period(P<0.05).②After treatment,the levels of ALB and Hb in the two groups were higher than those before treatment.The levels of ALB and Hb in the treatment group were(39.85±3.19)mg·L^(-1) and(107.73±17.84)g·L^(-1),respectively,higher than those in the control group(P<0.05).③After treatment,the TCM syndrome score in the treatment group was significantly lower than that before treatment,and significantly lower than that in the control group at the same period(P<0.05);The effective rate of TCM syndrome(58.0%)and clinical effective rate(82.0%)in the treatment group were higher than those in the control group(36.2%,55.3%)(P<0.05).Conclusion:Baoshen Mixture can effectively improve the renal function and nutritional status of patients,delay the progress of kidney disease,and alleviate clinical symptoms.
作者
颜中玉
刘晓静
邹燕勤
孟令栋
黄萍
沙鑫
YAN Zhongyu;LIU Xiaojing;ZOU Yanqin;MENG Lingdong;HUANG Ping;SHA Xin(Yangzhou Hospital of Traditional Chinese Medicine,Yangzhou Jiangsu China 225002)
出处
《中医学报》
CAS
2023年第1期187-191,共5页
Acta Chinese Medicine
基金
扬州市中医院院级科技项目(2022YNKT07B)。
关键词
慢性肾脏病
保肾合剂
尿素氮
血肌酐
肾小球滤过率
胱抑素C
血尿酸
白蛋白
血红蛋白
中医证候
chronic kidney disease
Baoshen Mixture
urea nitrogen
blood creatinine
glomerular filtration rate
cystatin C
blood uric acid
albumin
hemoglobin
TCM syndrome
