摘要
目的:观察星蒌承气汤纳米级微粒保留灌肠治疗脑出血合并肠道菌群紊乱的临床疗效。方法:回顾性分析100例脑出血合并肠道菌群紊乱患者临床资料,根据患者病情、家属服用药物依从性及使用中药灌肠意愿将其分为对照组1(32例)、对照组2(34例)及观察组(34例)。对照组1给予双歧杆菌四联活菌片治疗,对照组2给予双歧杆菌四联活菌片联合普通星蒌承气汤保留灌肠,观察组给予双歧杆菌四联活菌片联合星蒌承气汤纳米级微粒保留灌肠。结果:治疗后,观察组在大便外观、pH值≤5.5、球杆比(≤1/3)、双歧杆菌/肠杆菌(B/E>1)方面显著优于其余两组,差异有统计学意义(P<0.05)。观察组治疗1周时在大便外观、pH值≤5.5、球杆比(≤1/3)、双歧杆菌/肠杆菌(B/E>1)方面优于治疗3 d时,差异有统计学意义(P<0.05)。观察组神经功能恢复有效率显著高于其余两组,差异有统计学意义(P<0.05)。结论:星蒌承气汤纳米级微粒保留灌肠治疗脑出血合并肠道菌群紊乱疗效显著,可改善大便外观、球杆比、双歧杆菌/肠杆菌、神经功能。
Objective:to observe the Xinglou Chengqi Decoction nanoparticles retention enema clinical curative effect for treatment of cerebral hemorrhage with intestinal flora disorder.Methods:The clinical data of 100 patients with cerebral hemorrhage complicated with intestinal flora disturbance were retrospectively analyzed.The patients were divided into control group 1(32 cases),control group 2(34 cases)and observation group(34 cases)according to the patient′s condition,family members′compliance of taking medicine and willingness of enema with Chinese medicine.The control group 1 was treated with Bifidobacterium Tetravaccine Tablets for 32 cases,the control group 2 was treated with Bifidobacterium Tetravaccine Tablets combined with common Chinese medicine Xinglou Chengqi Decoction for 34 cases,and the observation group was treated with Bifidobacterium Tetravaccine Tablets combined with nano-Chinese medicine Xinglou Chengqi Decoction for 34 cases.Results:After treatment,the observation group was significantly better(P<0.05)than the other two groups in terms of stool appearance,pH≤5.5,ball-to-bar ratio(≤1/3),and Bifidobacterium/Enterobacter(B/E>1).The difference was statistically significant better than that at 3 days of treatment,and the difference was statistically significant(P<0.05).The recovery efficiency of neurological function in the observation group was significantly higher than that in the other two groups,and the difference was statistically significant(P<0.05).Conclusion:Xinglou Chengqi Decoction nanoparticle retention enema is effective in treatment of cerebral hemorrhage complicated with intestinal flora disturbance,which can improve the appearance of stool,ball rod ratio,bifidobacteria/enterobacteria and nerve function.
作者
薛娜
张东伟
XUE Na;ZHANG Dongwei(Zhengzhou Traditional Chinese Medicine Hospital,Zhengzhou Henan China 450000)
出处
《中医学报》
CAS
2023年第1期210-216,共7页
Acta Chinese Medicine
基金
国家自然科学基金项目(81260227)。
关键词
脑出血
肠道菌群紊乱
星蒌承气汤
灌肠
cerebral hemorrhage
intestinal flora disorder
Xinglou Chengqi Decoction
Chinese medicine enema
