摘要
目的 探讨碘对比剂不良反应与心脑血管狭窄程度的相关性,旨在提高对碘对比剂不良反应的认识。方法 回顾性分析山东大学齐鲁医院德州医院2015年7月至2022年4月进行头颈部及冠状动脉CTA检查的66例患者资料,所用患者均采用次高渗或等渗非离子碘对比剂,根据患者碘对比剂不良反应程度,分为轻度不良反应、中度不良反应、重度不良反应。次高渗和等渗非离子碘对比剂之间不良反应的发生率和严重程度的差异,使用χ^(2)检验进行评估。对所有病例的头颈及冠状动脉血管狭窄程度进行评分,利用Spearman相关分析评价碘对比剂不良反应严重程度与心脑血管狭窄程度的相关性。结果 次高渗和等渗非离子碘对比剂不良反应的发生率和不良反应程度,经χ^(2)检验,无统计学显著性差异(P>0.05);非离子碘对比剂不良反应严重程度与心脑血管狭窄程度之间呈低度相关(r=0.335,P=0.006)。结论 严重心脑血管疾病与碘对比剂不良反应具有一定相关性,应当警惕该类患者检查中可能发生的不良反应事件。
Objective To investigate the correlation between the adverse reactions of iodine contrast agents and the degree of cardiovascular and cerebrovascular stenosis, in order to improve the understanding of the adverse reactions of iodine contrast agents. Methods The data of 66 cases of adverse reactions of non-ionic iodine contrast agent in head and neck CTA and coronary CTA in Qilu Hospital of Shandong University Dezhou Hospital from July 2015 to April 2022 were analyzed retrospectively, and they were divided into mild, moderate and severe groups according to the severity of adverse reactions. Χ^(2) test was used to evaluate the difference in the incidence and severity of adverse reactions between secondary hypertonic and isotonic non-ionic iodine contrast agents. The degree of head and neck artery and coronary artery stenosis in all cases was scored, and the correlation between the severity of adverse reactions of iodine contrast agents and the degree of cardiovascular and cerebrovascular stenosis was evaluated by Spearman correlation analysis. Results There was no significant difference in the number of cases and the degree of adverse reactions between secondary hypertonic and isotonic contrast agents evaluated by Χ^(2)test(P>0.05). There was a weak correlation between the severity of adverse reactions with contrast media and the score of cardiovascular and cerebrovascular stenosis(R =0.335, P=0.006). Conclusion Serious cardiovascular and cerebrovascular diseases are related to adverse reactions of iodine contrast media to a certain extent, so we should be vigilant against allergic events that may occur in such patients during examination.
作者
邢腾龙
邢炳伟
解丙坤
张振红
霍宪凯
王蓉
XING Teng-long;XING Bing-wei;XIE Bing-kun;ZHANG Zhen-hong;HUO Xian-kai;WANG Rong(Imaging Department of Qilu Hospital of Shandong University Dezhou Hospital,Dezhou 253000,Shandong province,China;Imaging Department of Ningjin People's Hospital,Dezhou 253000,Shandong province,China)
出处
《中国CT和MRI杂志》
2023年第1期36-37,共2页
Chinese Journal of CT and MRI
基金
2020年度山东省伦琴影像科研专项(SD-202008-012)
2017年度山东省医药卫生科技发展计划项目(2017WS893)。
关键词
碘对比剂
不良反应
血管狭窄
相关性分析
Iodine Contrast Agent
Adverse Reactions
Cardiovascular and Cerebrovascular Stenosis
Correlation Analysis
