摘要
目的 观察五脏调治针刺法联合西药对有攻击行为的精神分裂患者攻击激越行为及神经递质水平的影响。方法 选取医院精神科2018年11月—2021年11月收治的有攻击行为的精神分裂患者86例,采用随机数字表法分为对照组和观察组。对照组43例单用盐酸多奈哌齐胶囊治疗,观察组则加用五脏调治针刺法治疗,连续治疗6周。检测两组神经递质全脑相对功率、脑功能指数的变化,比较两组阳性和阴性症状量表评分表(PANSS)、外显攻击行为量表(MOAS)、疗效及安全性。结果 基线时,神经递质全脑相对功率、脑功能指数组间比较,差异无统计学意义(P>0.05)。6周后,两组精神分裂者γ-氨基丁酸(GABA)除外的其他神经递质和兴奋抑制指数均低于基线时,血管舒缩指数与基线时比较,无统计学意义(P>0.05)。观察组6周后谷氨酸(Glu)、5-羟色胺(5-HT)、乙酰胆碱(Ach)、去甲肾上腺素(NE)和兴奋抑制指数均低于对照组,差异有统计学意义(P<0.05)。基线时,PANSS评分、MOAS评分组间比较,差异无统计学意义(P>0.05)。4周、6周后,两组精神分裂者PANSS评分、MOAS评分均低于基线时(P<0.05)。观察组4周、6周后上述评分低于对照组,有统计学意义(P<0.05)。观察组治疗6周后总有效率为93.02%(40/43)高于对照组的76.74%(33/43),总不良反应率为11.63%(5/43)与对照组的13.95%(6/43)比较,差异无统计学意义(P>0.05)。结论 五脏调治针刺法联合西药可减轻有攻击行为的精神分裂患者的攻击激越行为,提高疗效,可能和调节神经递质有关。
Objective To observe the effects of five Zang-organs regulating acupuncture combined with western medicine on aggressive behavior and neurotransmitter level in schizophrenic patients with aggressive behavior.Methods Eighty-six schizophrenic patients with aggressive behavior treated in the psychiatric department of the hospital from November 2018 to November 2021 were randomly divided into control group and observation group.Forty-three cases in the control group were treated with donepezil hydrochloride capsule alone, while the observation group was treated with five Zang-organs regulating acupuncture for 6 weeks.The changes of whole brain relative power and brain function index of neurotransmitters in the two groups were detected, and the rating scale of positive and negative symptoms(PANSS)score, Modified Overt Aggression Scale(MOAS)score, curative effect and safety of the two groups were compared.Results At baseline, there was no significant difference in the relative power of neurotransmitters in the whole brain and brain function index between the two groups(P>0.05).After 6 weeks, the neurotransmitters other than γ-aminobutyric acid(GABA)and excitation inhibition index in the two groups were lower than those at baseline, and the vasomotor index was not statistically significant compared with that at baseline(P>0.05).After 6 weeks, the levels of glutamic acid(Glu),5-hydroxytryptamine(5-HT),acetylcholine(Ach),norepinephrine(NE)and excitation inhibition index in the observation group were lower than those in the control group.There was statistical significance(P<0.05).At baseline, there was no significant difference in PANSS score or MOAS score between the two groups(P>0.05).After 4 and 6 weeks, the PANSS score and MOAS score of schizophrenics in the two groups were lower than those at baseline(P<0.05),and the above scores in the observation group were lower than those in the control group after 4 and 6 weeks(P<0.05).After 6 weeks of treatment, the total effective rate in the observation group was 93.02%(40/43),which was higher than 76.74%(33/43)in the control group.The total adverse reaction rate was 11.63%(5/43)and 13.95%(6/43)in the control group.There was no significant difference(P>0.05).Conclusion Five Zang-organs regulating acupuncture combined with western medicine can reduce the aggressive behavior of schizophrenic patients with aggressive behavior and improve the curative effect, which may be related to the regulation of neurotransmitters.
作者
杨华
宁若辰
YANG Hua;NING Ruochen(Jingzhou Mental Health Center,Jingzhou 434000,Hubei,China;Jingzhou Second Social Welfare Home,Jingzhou 434000,Hubei,China)
出处
《辽宁中医杂志》
CAS
2022年第12期165-168,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
五脏调治针刺法
攻击行为
精神分裂
神经递质
疗效
acupuncture for regulating five Zang-organs
aggressive behavior
schizophrenia
neurotransmitters
curative effect
