摘要
目的 探究乌灵胶囊结合长春胺缓释胶囊对突发性耳聋患者疗效、生活质量影响。方法 研究纳入门诊收治的93例突发性耳聋患者(2020年2月—2021年5月收治),采取随机数字表法将患者分成观察组(46例)与对照组(47例),对照组患者采取服用长春胺缓释胶囊治疗,观察组患者长春胺缓释胶囊+乌灵胶囊治疗,比较各组患者临床疗效、治疗前后症状积分(耳鸣、耳闷、眩晕)变化、纯音听阈值变化及血清可溶性血管细胞黏附分子-1(sVCAM-1)及细胞间黏附因子-1(ICAM-1)水平变化、不良反应情况、欧洲五维生活质量量表(EQ-5D-3L)评分变化。结果 与对照组(85.11%,40/47)相比,观察组有效率(97.83%,45/46)更高(P<0.05);治疗前,两组患者症状积分(耳鸣、耳闷、眩晕)、纯音听阈值、sVCAM-1及ICAM-1水平、EQ-5D-3L评分等指标比较(P>0.05),治疗后各组患者症状积分(耳鸣、耳闷、眩晕)、纯音听阈值、sVCAM-1及ICAM-1水平、EQ-5D-3L评分等指标均改善,观察组患者治疗后症状积分(耳鸣、耳闷、眩晕)、纯音听阈值、sVCAM-1及ICAM-1水平、EQ-5D-3L评分等指标优于对照组(P<0.05)。两组患者不良反应均较少,且症状轻微,对照组2例恶心,观察组1例恶心(P>0.05)。结论 乌灵胶囊结合长春胺缓释胶囊治疗突发性耳聋效果佳,患者听力情况显著改善,且不良反应少,且轻微,安全性较高,患者生活质量显著提升,值得应用。
Objective To explore the effect of Wuling Capsule(乌灵胶囊)combined with Vinblastine Sustained Release Capsule on the efficacy and quality of life of patients with sudden deafness.Methods A total of 93 patients with sudden deafness admitted to the outpatient department from February 2020 to May 2021 were divided into the observation group(46 cases)and the control group(47 cases)by random number table method.The control group was treated with Vinblastine Sustained Release Capsule,while the observation group was treated with Vinblastine Sustained Release Capsule+Wuling Capsule.The clinical efficacy,symptom scores(tinnitus,tiredness and vertigo),pure tone hearing threshold changes,serum levels of soluble vascular cell adhesion molecule-1(sVCAM-1)and intercellular adhesion factor-1(ICAM-1),adverse reactions and European five dimensional quality of life scale(EQ-5D-3L)scores were compared before and after treatment in two groups.Results Compared with that of the control group(85.11%,40/47),the effective rate of the observation group(97.83%,45/46)was higher(P<0.05).Before treatment,symptom scores(tinnitus,tightness,vertigo),pure tone hearing threshold,levels of sVCAM-1 and ICAM-1,EQ-5D-3L score and other indicators between two groups were not significant(P>0.05).After treatment,symptom scores(tinnitus,tiredness and vertigo),pure tone hearing threshold,levels of sVCAM-1 and ICAM-1,EQ-5D-3L score and other indicators were improved in two groups.After treatment,symptom scores(tinnitus,tiredness and vertigo),pure tone hearing threshold,levels of sVCAM-1 and ICAM-1,EQ-5D-3L score and other indexes in the observation group were better than those in the control group(P<0.05).Adverse reactions were few in both groups,and symptoms were mild.There were 2 cases of nausea in the control group and 1 case of nausea in the observation group(P>0.05).Conclusion Wuling Capsule combined with Vinblastine Sustained Release Capsule in the treatment of sudden deafness has a good effect.The hearing condition of patients has been significantly improved,and the adverse reactions are less and mild.It has high safety,and the quality of life of patients has been significantly improved.It is worth applying.
作者
朱晓月
孙越甲
岳鑫
宋维杰
王立娜
罗征
ZHU Xiaoyue;SUN Yuejia;YUE Xin;SONG Weijie;WANG Lina;LUO Zheng(Department of Otolaryngology,Tianjin Occupational Disease Prevention and Control Hospital,Tianjin 300000,China;Department of Psychiatry,Tianjin Anding Hospital,Tianjin 300074,China)
出处
《辽宁中医杂志》
CAS
2022年第11期69-72,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家重点研发计划项目(2018YFC1314304)。
关键词
突发性耳聋
乌灵胶囊
长春胺缓释胶囊
疗效
生活质量
不良反应
sudden deafness
Wuling Capsule乌灵胶囊
Vinylamine Sustained Release Capsule
curative effect
quality of life
adverse reactions
