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TGF-β1、IFN-γ及Treg水平变化与小儿支气管哮喘及疾病严重程度的相关性研究

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摘要 目的:分析血清转化生长因子-β1(Transforming Growth Factor-β1,TGF-β1)、γ干扰素(Interferon-γ,IFN-γ)水平和调节性T细胞(Regulatory T Cells,Treg)含量变化与小儿支气管哮喘疾病及严重程度的相关性。方法:选取本院收治的小儿支气管哮喘(Bronchial Asthma,BA)患者127例设为观察组,另选取同期于本院行体检各项指标正常的健康儿童113例为对照组。其中观察组进一步根据疾病的严重程度将患儿分为轻度组、中度组及重度组。检测空腹静脉血中TGF-β1、IFN-γ水平和Treg细胞含量,并采用Spearman对TGF-β1、IFN-γ及Treg水平变化与疾病程度进行相关性分析。结果:观察组TGF-β1水平明显高于对照组,IFN-γ水平、Treg细胞含量低于对照组(P<0.05)。TGF-β1水平随着疾病严重程度上升而上升,IFN-γ水平和Treg细胞含量随着疾病严重程度下降而下降(P<0.05)。血清TGF-β1水平与疾病严重程度呈正相关(P<0.05);血清IFN-γ水平和血中Treg细胞含量与疾病严重程度呈显著负相关(P<0.05)。结论:TGF-β1、IFN-γ水平及Treg与BA患儿疾病程度密切相关,可作为临床参考指标,为临床制定治疗方案提供依据。
出处 《四川生理科学杂志》 2022年第12期2161-2163,共3页 Sichuan Journal of Physiological Sciences
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