摘要
目的比较贫血在射血分数减低(HFrEF)、射血分数中间值(HFmrEF)和射血分数保留的心力衰竭(HFpEF)患者中的发生率及其相关因素。方法单中心回顾性队列研究。纳入并分析2018年6月至2020年5月在河北省人民医院住院治疗的937例慢性心力衰竭(CHF)患者的临床资料。根据左室射血分数将患者分为HFrEF组(377例)、HFmrEF组(193例)和HFpEF组(367例),比较三组CHF患者基线资料及贫血的发生率,通过二元logistic回归分析贫血的相关因素。结果937例CHF患者中,404例(43.1%)伴有贫血。其中,HFrEF组138例(36.6%),HFmrEF组74例(38.3%),HFpEF组192例(52.3%),三组间的贫血患病率的差异有统计学意义(P<0.001)。不贫血和贫血患者的年龄、慢性肾病和低蛋白血症率、肺动脉收缩压、血肌酐值、N末端B型利钠肽原、估算肾小球滤过率和脑啡肽酶抑制剂使用率等的差异均有统计学意义(均为P<0.05)。Logistic回归分析显示,年龄>65岁、合并慢性肾病和低蛋白血症的CHF患者更容易发生贫血(均为P<0.001)。结论HFpEF患者中贫血的发生率高于HFmrEF和HFrEF患者,不同HF表型合并症也可影响贫血的发生。
Objective To compare the prevalence and related factors of anemia in patients with reduced ejection fraction(HFrEF),mid-range ejection fraction(HFmrEF),and preserved ejection fraction(HFpEF).Methods This was a single-center,retrospective cohort study.A total of 937 patients with chronic heart failure(CHF)admitted to the People’s Hospital of Hebei Province from June 2018 to May 2020 were enrolled and the clinical data was analyzed.According to left ventricular ejection fraction,all CHF patients were divided into HFrEF group(n=377),HFmrEF group(n=193)and HFpEF group(n=367).Baseline data and incidence of anemia among the three groups were compared,and associated factors of anemia were analyzed by binary logistic regression.Results Among 937 CHF patients,404(43.1%)had anemia.The incidence of anemia among the three groups were significantly different[36.6%(138/377)vs.38.3%(74/193)vs.52.3%(192/367),P<0.001].Logistic regression analysis showed that CHF patients with age>65 years,or combined with chronic kidney disease or hypoproteinemia were more likely to have anemia(all P<0.001).Conclusions The incidence of anemia is higher in patients with HFpEF than in those with HFmrEF or HFrEF,and the comorbidities of different HF phenotypes may affect the incidence of anemia.
作者
王震
苏康康
杨晓月
王岩
田师鹏
王立立
陈淑霞
谷剑
Wang Zhen;Su Kangkang;Yang Xiaoyue;Wang Yang;Tian Shipeng;Wang Lili;Chen Shuxia;Gu Jian(Graduate School of Hebei Medical University,Shijiazhuang 050011,China;Graduate School of Hebei North University,Zhangjiakou 075000,China;Department of Cardiology,Hebei General Hospital,Shijiazhuang 050057,China)
出处
《中国心血管杂志》
2022年第6期525-530,共6页
Chinese Journal of Cardiovascular Medicine
关键词
心力衰竭
贫血
合并症
相关因素
Heart Failure
Anemia
Comorbidities
Related factor
