摘要
目的研究妊娠期糖尿病(GDM)血糖控制满意者血清胱抑素C(Cys-C)、同型半胱氨酸(Hcy)水平与妊娠结局的关系。方法将我院2019年2月至2022年2月收治的120例GDM血糖控制满意者纳为观察组,另将同期在我院检查并分娩的100名健康产妇纳为对照组,比较两组Cys-C、Hcy水平,分析两组不良妊娠结局发生情况,探索观察组不同妊娠结局患者Cys-C、Hcy水平,通过受试者工作特征(ROC)曲线分析Cys-C、Hcy对不良妊娠结局的预测价值。结果观察组血清Cys-C、Hcy水平显著高于对照组(t值分别为9.182和8.282,P<0.05)。观察组不良妊娠结局总发生率显著高于对照组(χ^(2)=8.398,P<0.05)。观察组结局不良者血清Cys-C、Hcy水平显著高于结局良好者(t值分别为4.062和5.052,P<0.05)。ROC分析表明Cys-C、Hcy能够用于不良妊娠结局的预测(P<0.05),Cys-C曲线下面积为0.745,截断值为1.275mg/L;Hcy曲线下面积为0.749,截断值为13.580μmol/L。Cys-C、Hcy与流产、早产、低出生体重儿、巨大儿、胎儿发育异常均呈正相关关系(r值为0.542~0.682,P<0.05)。结论GDM血糖控制满意者血清Cys-C、Hcy水平越高,其不良妊娠结局发生概率越大。
Objective To study the relationship between serum cystatin C(Cys-C),homocysteine(Hcy)levels and pregnancy outcomes in gestational diabetes mellitus(GDM)patients with satisfied glycaemic control.Methods A total of 120 gestational GDM patients with satisfied glycaemic control admitted to our hospital from February 2019 to February 2022 were enrolled as the observation group,and 100 healthy parturients examined and delivered in our hospital during the same period were enrolled as the control group,the levels of Cys-C and Hcy between the two groups were compared,the occurrence of adverse pregnancy outcomes in the two groups was analyzed,the levels of Cys-C and Hcy were explored in patients with different pregnancy outcomes in the observation group,and the predictive value of Cys-C and Hcy on adverse pregnancy outcomes was analyzed by receiver operating characteristic(ROC)curves.Results The serum levels of Cys-C and Hcy in the observation group were significantly higher than those in the control group(t=9.182 and 8.282,respectively,P<0.05).The total incidence of adverse pregnancy outcomes in the observation group was significantly higher than the control group(χ^(2)=8.398,P<0.05).The serum levels of Cys-C and Hcy in patients with poor outcome in the observation group were significantly higher than those in patients with good outcome(t=4.062 and 5.052,respectively,P<0.05).ROC analysis confirmed that Cys-C and Hcy could be used to predict adverse pregnancy outcomes(P<0.05).The area under the Cys-C curve was 0.745,and the cut-off value was 1.275 mg/L.The area under the Hcy curve was 0.749,and the cut-off value was 13.580μmol/L.Cys-C,Hcy were positively correlated with abortion,premature birth,low birth weight infants,macrosomia and fetal dysplasia(r value ranged from 0.542 to 0.682,P<0.05).Conclusion The higher the levels of serum Cys-C and Hcy in GDM patients with satisfied glycaemic control,the higher the probability of adverse pregnancy outcomes.
作者
施蒙娜
池振静
郑皓宇
SHI Mengna;CHI Zhenjing;ZHENG Haoyu(Department of Clinical Laboratory,the First Affiliated Huai'an Hospital of Nanjing Medical University,Jiangsu huai'an 223300,China;Department of Obstetrics,the First Affiliated Huai'an Hospital of Nanjing Medical University,Jiangsu huai'an 223300,China)
出处
《中国妇幼健康研究》
2022年第12期46-50,共5页
Chinese Journal of Woman and Child Health Research
关键词
妊娠期糖尿病
胱抑素C
同型半胱氨酸
妊娠结局
相关性
gestational diabetes mellitus
cystatin-C
homocysteine
pregnancy outcomes
correlation
