摘要
了解猪流行性腹泻疫苗免疫猪只后产生的抗体水平对防控猪流行性腹泻病有重要意义。本试验通过对未感染过PEDV的猪只进行PED活疫苗和灭活疫苗免疫,综合评估所产生的中和抗体、IgA和IgG抗体水平。结果显示,PED活疫苗免疫可以产生低水平(约1:10)的中和抗体,PED灭活疫苗免疫可以产生较高(约1:180)的中和抗体;PED活疫苗和PED灭活疫苗免疫均不能产生IgA抗体,免疫前后IgA均为阴性;PED活疫苗免疫产生IgG抗体为阴性,PED灭活疫苗免疫可以产生较高的IgG抗体(S/P值约3.0)。通过此项研究,可以对PEDV预防提供一定指导。
It was important to understand the antibody produced after immunization with porcine epidemic diarrhea vaccine to prevent infection and formulate prevention strategies.In this study,pigs without PEDV infection were immunized with PED vaccine and inactivated vaccine,and the neutralizing antibodies,IgA and IgG antibodies produced were comprehensively evaluated.The results showed that low level of neutralizing antibody(about 1:10) was produced by PED vaccine immunization,while high level of neutralizing antibody(about 1:180) was produced by PED inactivated vaccine immulization.IgA antibody could not be produced by either PED vaccine or PED inactivated vaccine,and IgA was negative before and after immunization.PED vaccine immunization produced negative IgG antibody,and PED inactivated vaccine immunization produced higher IgG antibody(S/P value about 3.0).This study could provide some guidance for PEDV prevention strategies.
作者
杜久斌
唐慧芬
潘晓梅
赵晓英
廖勇
刘强德
孙彦军
贺笋
DU Jiubin;TANG Huifen;PAN Xiaomei;ZHAO Xiaoying;LIAO Yong;LIU Qiangde;SUN Yanjun;HE Sun(Tecon Biopharmaceutical Co.Ltd,Urumqi 830001,China)
出处
《中国猪业》
2022年第6期75-77,82,共4页
China Swine Industry
