摘要
探讨小而密低密度脂蛋白胆固醇(sdLDL-C)在H型高血压患者中的表达及其与H型高血压和亚甲基四氢叶酸还原酶(MTHFR)基因多态性间的相关性。采用回顾性研究,选择2021年3月至2022年3月在山东省淄博市第一医院诊治的207例住院高血压患者,男76例,女131例,年龄40~82岁、中位数年龄66岁。检测同型半胱氨酸(Hcy)、sdLDL-C、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、甘油三酯(TG)、脂蛋白(a)[Lp(a)]水平。根据Hcy水平分为H型高血压组(105例,男性40例,女性65例)和非H型高血压组(102例,男性36例,女性66例),检测各组MTHFR C677T多态性,对H型高血压发生相关因素进行logistic回归分析。结果显示,H型高血压组和非H型高血压组血清sdLDL-C水平分别为(0.92±0.31)mmol/L和(0.65±0.28)mmol/L,H型高血压组sdLDL-C水平显著高于非H型高血压组(t=6.500,P<0.01),H型高血压组男性和女性的血清sdLDL-C水平差异无统计学意义(t=-1.543,P=0.129);H型高血压组MTHFR C677T的CC、CT、TT基因型和C、T等位基因频率与非H型高血压组相比差异有统计学意义(P<0.05);H型高血压组MTHFR不同基因型间Hcy和sdLDL-C水平差异有统计学意义(H=12.742,P=0.002;F=3.345,P=0.042)。其中H型高血压组TT基因型Hcy水平分别高于CC、CT基因型(Z=-28.099,P=0.003;Z=-16.112,P=0.040),TT基因型sdLDL-C水平高于CC基因型(t=-2.587,P=0.012)。logistic回归分析结果显示年龄、sdLDL-C和MTHFR C677T TT基因型与H型高血压发生有关。综上,sdLDL-C水平与MTHFR基因多态性及H型高血压发生可能有相关性。
To investigate the expression of small dense low-density lipoprotein cholesterol(sdLDL-C)in patients with H-type hypertension and its association with H-type hypertension and methylenetetrahydrofolate reductase(MTHFR)gene polymorphisms.The retrospective study method was used,and a total of 207 hospitalized hypertensive patients(76 males and 131 females,aged 40-82 years,median age 66 years)admitted to the Zibo First Hospital from March 2021 to March 2022 were enrolled in this study.The levels of homocysteine(Hcy),sdLDL-C,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),total cholesterol(TC),triglyceride(TG)and lipoprotein(a)[Lp(a)]were measured.The patients were divided into H-type hypertensive group(n=105,40 males and 65 females)and non-H-type hypertensive group(n=102,36 males and 66 females)according to Hcy levels.The C677T polymorphism of methylenetetrahydrofolate reductase(MTHFR)gene was detected in each group.Logistic regression analysis was performed for the related factors of H-type hypertension.The serum sdLDL-C levels were(0.92±0.31)and(0.65±0.28)mmol/L in H-type hypertension group and non-H-type hypertension group,respectively.The sdLDL-C levels in H-type hypertension group were significantly higher than those in non-H-type hypertension group(t=6.500,P<0.01).There was no significant difference in the serum sdLDL-C levels between males and females in H-type hypertension group(t=-1.543,P=0.129).The CC,CT,TT genotypes and C and T allele frequencies of MTHFR C677T in H-type hypertension group were significantly different from those in non-H-type hypertension group(P<0.05).The Hcy and sdLDL-C levels in different genotypes of MTHFR in H-type hypertension group were significantly different(H=12.742,P=0.002;F=3.345,P=0.042).Among them,Hcy levels were higher in TT genotype than in CT and CC genotypes,respectively(Z=-28.099,P=0.003;Z=-16.112,P=0.040),and sdLDL-C levels were higher in TT genotype than in CC genotype(t=-2.587,P=0.012).Logistic regression analysis showed that age,sdLDL-C,and MTHFRC677T TT genotypes were associated with the development for H-type hypertension.In conclusion,the level of sdLDL-C is associated with MTHFR gene polymorphisms and may be associated with the development of H-type hypertension.
作者
李庆
孙晓琳
宋波
吕承秀
丰新倩
Li Qing;Sun Xiaolin;Song Bo;Lyu Chengxiu;Feng Xinqian(Clinical Laboratory,Zibo First Hospital,Zibo 255200,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2022年第12期1844-1849,共6页
Chinese Journal of Preventive Medicine
基金
山东省医药卫生科技发展计划项目(2018WS008)。
