摘要
慢性肾脏病(CKD)具有发病率高、知晓率低、起病隐匿的特点。早期诊断和治疗对延缓其进展起着至关重要的作用。目前诊断CKD常用的生物学标志物受多种因素影响,具有一定的局限性,需进一步寻求CKD早期阶段敏感且准确的生物学标志物。血清人附睾蛋白4(HE4)是一种相对分子质量较小的、酸性的、半胱氨酸含量丰富的分泌性糖基化蛋白,具有抑制蛋白酶、参与炎症反应和促进细胞增殖、黏附的作用,在慢性肾脏病早期阶段即呈现高表达水平,与肾功能受损及肾脏纤维化程度密切相关,有望成为CKD和肾脏纤维化早期诊断和评估预后的潜在生物学标志物。因此该文从CKD和肾脏纤维化两个角度入手阐述了血清HE4的表达水平与慢性肾脏病和肾脏纤维化的关系及其表达水平的影响机制,进一步探究其临床意义,以期提高其临床应用价值并为临床研究提供新的思路。
Chronic kidney disease(CKD)has the characteristics of high incidence rate,low awareness and insidious onset.Early diagnosis and treatment play a vital role in delaying its progress.At present,the commonly used biomarkers for the diagnosis of CKD are affected by many factors and have certain limitations,so it is necessary to further seek sensitive and accurate biomarkers for the early stage of CKD.Serum human epididymal protein 4(HE4)is a relatively small in molecular weight,acidic,cysteine-rich,secreted glycosylated protein which could inhibit protease,participate in inflammatory reaction,promote cell proliferation and adhesion.It is highly expressed in the early stage of CKD and is closely related to renal function damage and renal fibrosis,thus being expected to become a potential biomarker for the early diagnosis and prognosis evaluation of CKD and renal fibrosis.Therefore,from the perspectives of CKD and renal fibrosis,this paper elaborates the relationship between serum HE4 level and CKD and renal fibrosis,and the mechanism of its expression,so as to further explore its clinical significance,thus improving its clinical application value and providing new ideas for clinical research.
作者
高冉冉
胡洪贞
韩聪
宋慧慧
申振
艾珊珊(综述)
李伟(审校)
GAO Ranran;HU Hongzhen;HAN Cong;SONG Huihui;SHEN Zhen;AI Shanshan;LI Wei(Shandong University of Traditional Chinese Medicine,Ji′nan,Shandong 250014,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Ji′nan,Shandong 250014,China)
出处
《国际检验医学杂志》
CAS
2023年第1期100-104,共5页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(82004282、82174179)
中国博士后科学基金项目(2021M702039)。
关键词
血清人附睾蛋白4
慢性肾脏病
肾脏纤维化
human epididymal protein 4
chronic kidney disease
kidney fibrosis
