摘要
Catalytic asymmetric aza-Michael represents one of the most convenient and atom-economical approaches for the rapid construction of biologically active chiralβ-amino acid frameworks.However,the direct enantioselective addition of nitrogen-based nucleophiles to intrinsically low reactivity ofα,β-unsaturated carboxylic acid,ester,and amide,as well as simpleα,β-unsaturated nitrile,remains a long-standing challenge.
基金
the National Natural Science Foundation of China(grant nos.21672033,21801039,and 21831002)
the Jilin Educational Committee(grant no.JJKH20190269KJ)
the Fundamental Research Funds for the Central Universities,and the Ten Thousand Talents Program for generous financial support.
