摘要
目的探究安神补心丸联合氟西汀在合并睡眠障碍中风后抑郁(PSD)患者中的应用效果。方法选取2019年6月—2020年7月合并睡眠障碍PSD患者98例,根据治疗方案不同分为观察组、对照组,各49例。对照组给予氟西汀治疗,观察组在此基础上加用安神补心丸治疗。观察两组疗效、治疗前后神经功能缺损情况(SNSS)、抑郁情况(HAMD)、睡眠质量(PSQI)、病情相关因子[血清S100β蛋白、C反应蛋白(CRP)、神经营养因子-3(NT-3)、脑源性神经营养因子(BDNF)]水平及不良反应率。结果观察组总有效率为95.92%,高于对照组的79.59%(P<0.05);治疗1周后、4周后观察组HAMD、PSQI评分低于对照组(P<0.05);治疗4周后观察组SNSS评分高于对照组(P<0.05);治疗1周后、4周后与对照组相比,观察组S100β蛋白、NT-3、CRP水平较低,BDNF水平较高(P<0.05);两组不良反应率比较差异无统计学意义(P>0.05)。结论氟西汀+安神补心丸治疗合并睡眠障碍PSD患者疗效确切,可有效改善患者抑郁情绪,提高睡眠质量。
Objective To investigate the application effect of Anshen Buxin Pill combined with fluoxetine in patients with post-stroke depression(PSD)complicated with sleep disorder.Methods 98 patients with PSD complicated sleep disorder in the First People's Hospital of Pingdingshan City from June 2019 to July 2020 were selected and divided into study group and control group according to different treatment plans,with 49 cases in each group.The control group were treated with fluoxetine,and the study group were additionally given Anshen Buxin Pill on the basis of control group.And then,the curative effects,and neurological function deficit(SNSS),depression(Hamilton Depression Scale,HAMD),sleep quality(Pittsburgh Sleep Quality Index,PSQI)before and after treatment as well as levels of disease-related factors(serum S100βprotein,C-reactive protein[CRP],neurotrophic factor-3[NT-3],brain-derived neurotrophic factor[BDNF])and incidence of adverse reactions were observed among the two groups.Results The total efficacy of the study group was 95.92%,higher than that of the control group(79.59%)(P<0.05);the HAMD and PSQI scores of the study group were lower than those of the control group after 1 week and 4 weeks of treatment(P<0.05);the SNSS score of the study group was higher than that of the control group after 4 weeks of treatment(P<0.05);compared with the control group after 1 week and 4 weeks of treatment,the study group had lower levels of S100βprotein,NT-3,and CRP,but higher level of BDNF(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Fluoxetine+Anshen Buxin Pills is effective in the treatment of patients with PSD complicated with sleep disorder,which can effectively improve the depression and sleep quality of the patients.
作者
刘凯
赵志华
LIU Kai;ZHAO Zhihua(Department of Neurology,The First People's Hospital of Pingdingshan City,Pingdingshan 467000,Henan,China)
出处
《右江医学》
2022年第12期935-939,共5页
Chinese Youjiang Medical Journal
关键词
安神补心丸
中风后抑郁
氟西汀
睡眠障碍
Anshen Buxin Pill
post-stroke depression
fluoxetine
sleep disorder
