摘要
银屑病的发病机制十分复杂,涉及多基因、多细胞、多因子,这些因素通过一系列级联反应将信号进行逐层传递,从而形成了疾病发生的众多生物学通路,对于银屑病相关信号通路的研究已经成为疾病机制探索和药物干预的核心方式。在银屑病相关的所有信号通路中,以Janus酪氨酸蛋白激酶(JAK)/信号转导及转录激活因子(STAT)信号通路最为经典,JAK/STAT信号通路在长期的细胞信号传递进化过程中被选择和放大,以其通路的简洁性、稳定性,参与疾病炎症、免疫调控等环节,将JAK/STAT信号通路作为切入点和突破口的研究,有助于重新梳理和发现银屑病微观机制下的上、下游相关靶点调控方式,不断延伸银屑病机制的探索和认识。该文整理了具有清、消、补功效作用的中药复方制剂及麻黄、靛玉红、厚朴酚、人参皂苷CK、紫草素、芍药苷、丹皮酚、雷公藤多苷等中药单体和成分参与下的JAK/STAT信号通路靶位的相关研究,并将其成果整合,提炼出不同诱导因子如白细胞介素(IL)-6、IL-21、IL-22、IL-23、γ干扰素(IFN-γ)、细胞因子信号转导抑制因子1/3(SOCS1/3)等作用下的JAK/STAT信号通路家族亚型,同时,以JAK/STAT信号通路为特异性参照手段,探讨了其在银屑病血分分型和地域性患者群体中表达的差异,从而为银屑病的机制深入探索和临床靶向诊治提供一定的参考和依据。
The pathogenesis of psoriasis is very complex,involving multiple genes,cells,and factors.These factors signal layer by layer through a series of cascade reactions,thus forming many biological pathways of disease occurrence.The study of the psoriasis-related signaling pathway has become the core way of disease mechanism exploration and drug intervention.Among all the signaling pathways related to psoriasis,Janus kinase(JAK)/signal transducer and activator of transcription protein(STAT)signaling pathway is the top classic one.The JAK/STAT signaling pathway has been selected and amplified in the long-term evolution of the transmission of cellular signaling.It participates in inflammation,immune regulation,and other links of diseases because of its simplicity and stability.Taking the JAK/STAT signaling pathway as the entry point and breakthrough can facilitate the summarization and discovery of the regulation modes of upstream and downstream targets under the micromechanism of psoriasis,and continuously promote the exploration and understanding of the mechanism of psoriasis.This study analyzed the targets of the JAK/STAT signaling pathway with the participation of Chinese medicinal compound preparations with clearing,resolving,and tonifying effects and monomers and main components,such as Ephedrae Herba,indirubin,magnolol,ginsenoside CK,shikonin,paeoniflorin,paeonol,and Tripterygium wilfordii glucosides.The results were integrated into the JAK/STAT signaling pathway family subtypes under the action of different inducers such as interleukin(IL)-6,IL-21,IL-22,IL-23,interferon-γ(IFN-γ),and suppressors of cytokine signaling 1/3(SOCS1/3)for the first time.Meanwhile,taking JAK/STAT signaling pathway as a specific reference means,this study discussed the differences in expression in the classification of psoriasis based on blood aspect and regional patient groups to provide references for further exploration of the mechanism and clinical targeted diagnosis and treatment of psoriasis.
作者
吴咚咚
曹珣
安月鹏
WU Dongdong;CAO Xun;AN Yuepeng(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affiliated Hospital of Harbin Medical University,Harbin 150007,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第1期258-269,共12页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81904201,81973846)
国家重点研发计划“中医药现代化研究”重点专项课题(2018YFC1705301)
黑龙江省博士后资助经费项目(LBH-Z20198)
黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2020229)。
