摘要
肺动脉高压(PH)是一种不同病因及发病机制引起的肺血管结构或者功能的改变,从而引起肺血管阻力及肺动脉压力进行性升高的疾病。PH的发病机制涉及到多个方面,炎症机制在其中扮演着重要的角色。高迁移率族蛋白B1(HMGB1)是一种核蛋白,正常情况下其在细胞核中与DNA结合,参与DNA的复制和修复。而在应激条件下,其释放到胞质及胞外发挥不同的作用。近年来,多项研究证明HMGB1在PH的发生发展中扮演着一定的角色,在实验性PH的治疗中,靶向HMGB1展示了一定的潜能。本文立足于HMGB1,结合其生物学特点,综述HMGB1在不同的细胞位置对PH的发生发展中的作用,为治疗PH提供一条新的思路与途径。
Pulmonary hypertension(PH)is a structural or functional disorder of pulmonary blood vessels changed by different etiologies and pathogenesis,resulting in pulmonary vascular resistance and progressively increased pulmonary artery pressure.The pathogenesis of PH involves many aspects,among which,the inflammatory response is of great significance.High-mobility group box 1(HMGB1)is a nuclear protein that normally binds to DNA in the nucleus,which is involved in the control of DNA repair and replication processes.Stimulated by stress,it exerts different roles by being released to the cytoplasm and the extracellular microenvironment.Recent preclinical studies have demonstrated the role of HMGB1 in the occurrence and development of PH.Targeting HMGB1 is a promising therapeutic strategy for PH.This review summarizes the biological characteristics of HMGB1 in different cellular components that influence the occurrence and development of PH.Our findings provide novel directions in the treatment of PH.
作者
吕倩
成孟瑜
Lyu Qian;Cheng Mengyu(Department of Respiratory and Critical Care Medicine,the Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,China)
出处
《国际呼吸杂志》
2022年第23期1761-1766,共6页
International Journal of Respiration
基金
山西省回国留学人员科研资助项目(2020178)
山西省留学人员科技活动择优资助项目(20200029)。
