摘要
目的 探讨老年急性呼吸窘迫综合征(ARDS)患者经盐酸氨溴索辅助机械通气治疗的临床疗效。方法 我院收治的104例ARDS患者,其中机械通气治疗48例(对照组)、盐酸氨溴索辅助机械通气治疗56例(联合组)。对比两组治疗后7 d临床疗效、平均动脉压(MAP)、心率(HR)、氧合功能及炎性因子水平。结果 两组临床疗效比较差异无统计学意义(P>0.05);治疗后两组HR值均降低,联合组较对照组更低(P<0.05),两组MAP值比较差异无统计学意义(P>0.05);治疗后两组氧合功能均升高,联合组较对照组更高(P<0.05);治疗后两组肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素-10(IL-10)水平均降低,联合组较对照组更低(P<0.05)。结论 盐酸氨溴索辅助机械通气治疗可提高老年ARDS患者抗炎能力,改善其氧合,提升治疗效果,具有一定的临床使用价值。
Objective To investigate the clinical efficacy of ambroxol hydrochlorideassisted mechanical ventilation in the treatment of elderly patients with acute respiratory distress syndrome(ARDS).Methods One hundred and four ARDS patients treated in our hospital were selected. Among the patients, 48 were treated with mechanical ventilation(control group), and 56 were treated with ambroxol hydrochlorideassisted mechanical ventilation(combined group). The clinical efficacy, mean arterial pressure(MAP), heart rate(HR), oxygenation function and inflammatory factor levels were compared between the two groups after 7 days of treatment.Results There was no significant difference in the total effective rate between the two groups(P>0.05).HR values were decreased after treatment in both groups, and the combined group was lower than the control group(P<0.05). There was no difference in MAP valuesbetween the two groups(P>0.05).After treatment, the oxygenation function of the two groups was increased, and the improvement in the combined group was more obvious than that in the control group(P<0.05).After treatment, the levels of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) and interleukin-10(IL-10) in the two groups were all decreased, andthe levels of the inflammatory factors in the combined group were lower than those in the control group after treatment(P<0.05).Conclusions Ambroxol hydrochlorideassisted mechanical ventilation therapy can improve the anti-inflammatory ability, improve the oxygenation, and improve the therapeutic effect of elderly patients with ARDS.It has a certain clinical value.
作者
金明月
马文秀
张珈畅
王亚丽
JIN Ming-yue;MA Wen-xiu;ZHANG Jia-chang;WANG Ya-li(Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)
出处
《实用医院临床杂志》
2023年第1期104-107,共4页
Practical Journal of Clinical Medicine
关键词
盐酸氨溴索
机械通气
老年
急性呼吸窘迫综合征
临床疗效
炎性因子
Ambroxol hydrochloride
Mechanical ventilation
Elderly
Acute respiratory distress syndrome
Clinical efficacy
Inflammatory factors
