摘要
目的 探讨布地奈德/福莫特罗吸入与辛伐他汀结合治疗老年慢性阻塞性肺疾病(COPD)稳定期患者的疗效。方法 我院收治的94例老年COPD稳定期患者,对照组(n=47)采用常规治疗+布地奈德/福莫特罗吸入治疗,试验组(n=47)在对照组基础上联合辛伐他汀治疗,均连续治疗3个月后比较两组疗效及相关指标。结果 试验组治疗有效率高于对照组(P<0.05);治疗后两组气道重塑水平下降、6分钟步行距离测试(6MWT)评分上升,试验组均优于对照组(P<0.05);两组γ干扰素(IFN-γ)、IFN-γ/白介素-6(IL-6)上升,IL-6下降,试验组均优于对照组(P<0.05)。结论 布地奈德/福莫特罗联合辛伐他汀可提升老年COPD治疗有效率、改善气道重塑、提升运动耐力和改善Th1/Th2细胞因子水平。
Objective To investigate the efficacy of budesonide/formoterol inhalation combined with simvastatin in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD) at stable stage.Methods Ninety-four elderly patients with stable COPD were treated in our hospital. The control group(n =47) was treated with conventional therapy+budesonide/formoterol inhalation, and the experimental group(n =47) was treated with simvastatin on the basis of the control group. The efficacy and related indicators after 3 months of continuous treatment were compared between the two groups.Results The effective rate of the experimental group was higher than that of the control group(P<0.05). After treatment, the level of airway remodeling was decreased, and the score of 6-minute walking distance test(6MWT) was increased in both groups. The experimental group was better than the control group(P<0.05). The levels of interferon-γ(IFN-γ) and IFN-γ/Interleukin-6(IL-6) were increased and IL-6 was decreased in both groups, and the experimental group was better than that in the control group(P<0.05).Conclusions The combination of budesonide/formoterol and simvastatin can improve the therapeutic efficacy, airway remodeling, exercise tolerance and Th1/Th2 cytokine level in elderly patients with COPD.
作者
杨轶
雷璐
郑红
YANG Yi;LEI Lu;ZHENG Hong(Panzhihua Hospital of Integrated Traditional Chinese and Western Medicine,Panzhihua 617000,China)
出处
《实用医院临床杂志》
2023年第1期139-142,共4页
Practical Journal of Clinical Medicine
