摘要
目的 研究诺如病毒肠道排毒规律,找出影响其肠道排毒时间的因素。方法 采集深圳市龙华区3起发生诺如病毒感染性腹泻暴发疫情中涉疫人群的肛拭子标本并检测,定期监测并计算排毒期,分析临床症状和基本特征等排毒期的影响。结果 共监测3起聚集性疫情涉及255名对象,型别均为GII型,纳入研究对象91名。采取停课措施后(疫情发生后3~5 d),病毒感染率达到最高值,幼儿较成人的排毒时间更长(HR=0.235,P<0.001),不同岗位人群排毒期比较差异有统计学意义(H=8.528,P=0.014)。学生病例中未发热感染者较发热病例(HR=2.281,P=0.025)排毒期更长。结论 诺如病毒隐性感染者和病例在班级复课后仍持续带毒,二者排毒期无差异,但学生群体中隐性感染者较病例排毒期更长,易造成疫情二次传播风险。
Objective To study the regularity of norovirus intestinal detoxification and to find out the factors affecting norovirus intestinal detoxification time. Methods To collect and test the anal swabs of the people involved in three outbreaks of norovirus infectious diarrhea in Longhua district of Shenzhen City, and regularly monitor and calculate the detoxification period, to analyze the influence of detoxication period on clinical symptoms and basic characteristics. Results A total of 255 subjects, all of which were GII type, were monitored in 3 clusters of 91 subjects. After the suspension of classes(3-5 days after the outbreak), the virus infection rate reached its highest level, the detoxication time of infants was longer than that of adults(HR=0.235, P<0.001), and the detoxication time of different groups was significantly different(H=8.528, P=0.014). The detoxication period of non-febrile patients was longer than that of febrile patients(HR=2.281, P=0.025). Conclusions There was no difference in the detoxification period between the patients with latent norovirus infection and the patients with latent norovirus infection, but the patients with latent norovirus infection had a longer detoxification period than the patients with latent norovirus infection.
作者
张蔚
古子豪
满云翔
陈宏标
黄晓云
贺深莉
ZHANG Wei;GU Zi-hao;MAN Yun-xiang;CHEN Hong-biao;HUANG Xiao-yun;HE Shen-li(Department of Epidemiology and Infectious Disease Control,Longhua Centre for Disease Control and Prevention,Shenzhen 518109,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2022年第12期1468-1472,共5页
Chinese Journal of Disease Control & Prevention
基金
深圳市龙华区医疗卫生机构2021年区级科研项目(2021108)。
关键词
诺如病毒
排毒期
腹泻
Norovirus
Detoxication period
Diarrhea
