摘要
胰十二指肠切除术(PD)是治疗恶性肿瘤如胰头癌、壶腹周围癌及某些良性交界性疾病的首选术式。由于其涉及多个器官及组织的切除,术后并发症发生率高达30%~60%,包括出血、吻合口漏、感染等,其中以吻合口漏为主要并发症。因此选择良好的动物模型练习PD后消化道重建,对研究疾病并发症的发生率以及改善患者预后具有重要作用。为此笔者从不同层面对比了不同动物之间、动物与人类之间的相似性、解剖特点以及不同动物的经济性、可操作性、伦理原则等,欲探索最适合PD后消化道重建的动物模型,为降低术后并发症发生奠定实验基础。
Pancreaticoduodenectomy(PD)is the first choice for the treatment of malignant tumors such as pancreatic head carcinoma,periampullary carcinoma and some benign borderline diseases.Because it involves the resection of multiple organs and tissues,the incidence of postoperative complications is as high as 30%~60%,including bleeding,anastomotic leakage,infection,etc.,among which anastomotic leakage is the main complication.Therefore,choosing a good animal model to practice digestive tract reconstruction after PD plays an important role in studying the incidence of disease complications and improving the prognosis of patients.Therefore,the author compared the similarities and anatomical characteristics between different animals and between animals and humans from different levels,as well as the economy,operability and ethical principles of different animals,in order to explore the most suitable animal model for digestive tract reconstruction after PD,and lay the experimental foundation for reducing the occurrence of postoperative complications.
作者
郭艳
张明
牛河源
孟兴凯
Guo Yan;Zhang Ming;Niu Heyuan;Meng Xingkai(Department of Hepatobiliary,Pancreatic and Splenic Surgery,Affiliated Hospital of Inner Mongolia Medical University,Hohhot Inner Mongolia Autonomous Region O10050,China)
出处
《中华普外科手术学杂志（电子版）》
2023年第1期101-104,共4页
Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)
基金
内蒙古医科大学附属医院重大课题基金(NYFYZD2014005)。
关键词
胰十二指肠切除术
消化道重建
模型
动物
Pancreaticoduodenectomy
Digestive Tract Reconstruction
Models,Animal
