摘要
目的:分析祛风骨痛巴布膏联合针灸治疗腰椎间盘突出症的临床效果及对血清神经激肽1、神经肽Y及炎症因子的影响。方法:选取北京市应急总医院2019年9月-2021年9月收治的300例腰椎间盘突出症患者作为本次研究的观察对象,采用双色球法将其随机分为对照组(针灸治疗)、观察组(祛风骨痛巴布膏联合针灸治疗),各150例。对比两组的临床疗效、日本骨科协会腰部功能评分(JOA)、现有疼痛评分(PPI)、血清神经激肽1、神经肽Y指标及炎症因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]。结果:观察组总有效率为92.67%,高于对照组的78.67%,差异有统计学意义(P<0.05)。治疗后,观察组的JOA评分(22.31±4.51)分,显著高于对照组的(18.19±5.26)分,PPI评分为(1.31±0.22)分,低于对照组的(2.61±0.31)分,差异有统计学意义(P<0.05)。治疗后,观察组的神经激肽1为(12.11±5.02)pg/ml,神经肽Y为(112.30±4.62)pg/ml,显著低于对照组的(26.15±4.21)pg/ml和(154.19±5.11)pg/ml,差异有统计学意义(P<0.05)。治疗后,观察组的IL-1β、TNF-α、IL-6指标水平均低于对照组,差异有统计学意义(P<0.05)。结论:祛风骨痛巴布膏联合针灸治疗腰椎间盘突出症的临床疗效及对血清神经激肽1、神经肽Y及炎症因子的影响效果显著,值得推广。
Objective:To analyze the clinical efficacy of Qufeng Gutong Cataplasm combined with acupuncture in the treatment of lumbar disc herniation and its effect on serum neurokinin 1,neuropeptide Y and inflammatory factors.Method:A total of 300 patients with lumbar disc herniation treated in the Emergency General Hospital in Beijing from September 2019 to September 2021 were selected as the observation objects of this study.They were randomly divided into the control group(acupuncture treatment)and the observation group(Qufeng Gutong Cataplasm combined with acupuncture treatment)by double color ball method,150 cases in each group.The clinical efficacy,Japanese Orthopedic Association lumbar function score(JOA),present pain intensity(PPI)score,serum neurokinin 1,neuropeptide Y index and inflammatory factors[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)]of the two groups were compared.Result:The total effective rate of the observation group was 92.67%,which was significantly higher than 78.67% in the control group,the difference was statistically significant(P<0.05).After treatment,the JOA score in the observation group was(22.31±4.51)points,which was significantly higher than(18.19±5.26)points in the control group,and the PPI score was(1.31±0.22)points,which was lower than(2.61±0.31)points in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of neurokinin 1 and neuropeptide Y in the observation group were(12.11±5.02)pg/ml and(112.30±4.62)pg/ml,which were significantly lower than(26.15±4.21)pg/ml and(154.19±5.11)pg/ml in the control group,respectively,the differences were statistically significant(P<0.05).After treatment,the levels of IL-1β,TNF-α and IL-6 in observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Qufeng Gutong Cataplasm combined with acupuncture has a significant clinical effect on lumbar disc herniation and has a significant effect on serum neurokinin 1,neuropeptide Y and inflammatory factors,which is worthy of popularization.
作者
王大民
丁玲
WANG Damin;DING Ling(Emergency General Hospital in Beijing,Beijing 100028,China;不详)
出处
《中外医学研究》
2022年第36期110-114,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
祛风骨痛巴布膏
针灸
腰椎间盘突出症
临床效果
Qufeng Gutong Cataplasm
Acupuncture
Lumbar disc herniation
Curative effect
