摘要
目的:研究氟西汀联合基于中医气机升降理论治疗对乳腺癌合并抑郁患者情绪状况的影响。方法:选取2019年1月至2021年12月我院收治的106例乳腺癌合并抑郁患者为研究对象,采用随机数字表法,将患者划分为对照组、研究组,每组各53例。对照组患者采用氟西汀治疗,研究组患者采用氟西汀联合基于中医气机升降理论治疗。对比两组患者临床疗效、治疗前和治疗1个月后的汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分,及血清神经递质5-羟色胺(5-HT)、神经肽Y(NPY)、多巴胺(DA)、去甲肾上腺素(NE)水平。结果:研究组患者的治疗总有效率(94.34%)高于对照组(81.13%)(P<0.05);治疗1个月后,研究组患者HAMD、HAMA评分均低于对照组患者(P<0.05),研究组患者5-HT、NPY、DA、NE水平均高于对照组患者(P<0.05)。结论:在乳腺癌合并抑郁患者中采用氟西汀联合基于中医气机升降理论治疗,能提高临床疗效,并通过上调血清神经递质水平来改善患者的抑郁情绪。
Objective:To study the effects of integrated traditional Chinese and westen medicine treatment based on TCM Qi ascending and descending theory in the treatment of breast cancer patients with depression. Methods:106 cases of breast cancer patients with depression admitted to our hospital from January 2019 to December 2021 were selected as the research objects. The patients were divided into the control group and the study group by random number table method, with 53 cases in each group. The control group was treated with fluoxetine, and the study group was treated with fluoxetine combined with treatment based on TCM Qi ascending and descending theory. The clinical efficacy, scores of Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA) and the level of serum neurotransmitters 5-hydroxytryptamine(5-HT), neuropeptide Y(NPY), dopamine(DA), norepinephrine(NE) of the two groups of patients were compared before the treatment and one month after the treatment. Results:The total effective rate of the study group(94.34%) was higher than that of the control group(81.13%)(P<0.05). After one month of treatment, the HAMD and HAMA scores of patients in the study group were lower than those of the control group(P<0.05), and the levels of 5-HT, NPY, DA and NE of patients in the study group were higher than those in the control group(P<0.05). Conclusion:Fluoxetine combined with treatment based on TCM Qi ascending and descending theory can improve the clinical efficacy in breast cancer patients with depression, and improve the depression of patients by upregulating the level of serum neurotransmitters.
作者
钟敏
朱海军
蒋冬梅
周洁
朱丽娜
ZHONG Min;ZHU Haijun;JIANG Dongmei;ZHOU Jie;ZHU Lina(Department of Medical Oncology,Chang′an Hospital,Shaanxi Xi′an 710016,China;Department of General Surgery,Xi′an Central Hospital,Shaanxi Xi′an 710043,China)
出处
《中国医药导刊》
2022年第12期1242-1245,共4页
Chinese Journal of Medicinal Guide
关键词
乳腺癌合并抑郁
氟西汀
气机升降理论
血清神经递质
Breast cancer complicated with depression
Fluoxetine
The theory of Qi ascending and descending
Serum neurotransmitters
