摘要
端粒是位于染色体末端的DNA的非编码重复序列,能随着细胞分裂和DNA的复制而缩短,具有维持染色体稳定及保护染色体结构等功能。越来越多的研究发现,外周血白细胞端粒长度的缩短与动脉粥样硬化、高血压、脑卒中等心脑血管疾病和糖尿病等发病过程密切相关,并可能作为心脑血管疾病风险的预测因子,也有望成为心脑血管疾病治疗的新靶点。然而,端粒长度与心脑血管疾病及糖尿病之间的因果关系尚有争议,需要更多的研究探索端粒在心血管疾病中扮演的角色。
Telomeres are non-coding repeats of DNA which located at the end of chromosomes.They can be shorten alone with cell division and DNA replication,and have functions such as maintaining chromosome stability and protecting chromosome structure.More and more studies demonstrate that the shortening of peripheral leukocyte telomere length is closely related to atherosclerosis,hypertension,stroke and other cardiovascular/cerebrovascular diseases,as well as diabetes.They may be as a predictor risk of cardiovascular and cerebrovascular disease,and is also expected to become a new target for the treatment of cardiovascular and cerebrovascular diseases.However,the causal relationship between telomere length and cardiovascular disease or diabetes is still controversial,and more researches need to explore the role of telomere in cardiovascular disease.
作者
邹昕宇
杨帆
吴建军
邢磊
ZOU Xinyu;YANG Fan;WU Jianjun;XING Lei(Department of Cardiology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China;Key Laboratory of Myocardial Ischemia,Ministry of Education,The Second Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)
出处
《心血管病学进展》
CAS
2022年第12期1131-1133,共3页
Advances in Cardiovascular Diseases
