摘要
目的 观察三甲复脉颗粒对帕金森病(PD)阴虚血瘀证患者脑内神经递质功能平衡的影响及其对智能认知、睡眠的临床疗效。方法 将符合纳入标准的PD阴虚血瘀证患者59例随机分为两组,入组前西药剂量调至稳定,研究期间剂量维持不变,对照组仅西药治疗,试验组三甲复脉颗粒+西药治疗,两组患者均连续服用8周。比较两组患者干预前后脑内神经递质相对功率、简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)、帕金森病睡眠量表(PDSS)。结果 对照组干预前后脑内神经递质相对功率及MMSE、MoCA、PDSS评分无明显差异,试验组干预后脑内多巴胺(DA)、5-羟色胺(5-HT)、γ-氨基丁酸(GABA)相对功率及MMSE、MoCA、PDSS评分均高于干预前(P<0.05)。干预后,试验组5-HT、GABA相对功率及MMSE、MoCA、PDSS评分比较对照组升高(P<0.05)。结论 三甲复脉颗粒联合西药治疗能提高PD患者脑内DA、5-HT、GABA相对功率,改善智能认知、睡眠状况,有利于PD患者脑内神经递质功能平衡的构建。
Objective To observe the effect of Sanjiafumai Granules(三甲复脉颗粒)on functional balance of neurotransmitters in the brain of patients with Parkinson′s disease(PD)of Yin deficiency and blood stasis syndrome and its clinical effect on intelligent cognition and sleep.Methods Fifty-nine PD patients with Yin deficiency and blood stasis syndrome were randomly divided into two groups.Before entering the group,the dosage of Western medicine was adjusted to be stable,and the dosage remained unchanged during the study period.The control group was only treated with western medicine,and the experimental group was treated with Sanjiafumai Granules and Western medicine.Both groups were treated for 8 weeks.The relative power of neurotransmitters,Mini Mental State Examination(MMSE),Montreal Cognitive Assessment Scale(MoCA)and Parkinson′s disease Sleep Scale(PDSS)were compared between the two groups before and after intervention.Results There was no significant difference in the relative power of neurotransmitters and MMSE,MoCA and PDSS scores in the control group before and after the intervention,but there was significant difference in the relative power of dopamine(DA),5-hydroxytryptamine(5-HT)andγ-GABA as well as MMSE,MoCA and PDSS scores in the experimental group after the intervention were higher than those before intervention(P<0.05).After the intervention,5-HT and GABA relative power and MMSE,MoCA and PDSS scores of the experimental group were higher than those of the control group(P<0.05).Conclusion Sanjia Fumai Granules combined with Western medicine can improve the relative power of DA,5-HT and GABA in the brain of PD patients,improve the intelligent cognition and sleep status,and is conducive to the construction of functional balance of neurotransmitters in the brain of PD patients.
作者
唐一华
周德生
陈瑶
齐婧
刘利娟
张婷
TANG Yihua;ZHOU Desheng;CHEN Yao;QI Jing;LIU Lijuan;ZHANG Ting(Guilin Hospital of Traditional Chinese Medicine,Guilin 541000,Guangxi,China;The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China)
出处
《辽宁中医杂志》
CAS
2022年第10期6-9,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金湖南省科技厅科技创新平台与人才计划湖南省中医药管理局资助项目湖南中医药大学校级科研基金(ZYYDX201730)
湖南省科技厅重点专项(2017SK2111)
湖南省重点研发计划(2020SK2092)
湖南省级财政中医药项目名院工程院内优势病种(rsk-010-13 [006-09])
中医内科学重大疾病防治及成果转化-教育部重点实验室开放基金(ZYNK201609)
湖南省中医补助专项—中医质量控制中心(ywk-010-11)。
关键词
帕金森病
阴虚血瘀证
三甲复脉颗粒
脑超慢涨落图
神经递质
Parkinson′s disease
Yin deficiency and blood stasis syndrome
Sanjia Fumai Granules(三甲复脉颗粒)
encephalofulctuography
neurotransmitter
