摘要
目的 探讨参芪补肺方联合噻托溴铵粉吸入剂对慢性阻塞性肺疾病(COPD)患者中性粒细胞弹性蛋白酶(NE)、D-二聚体(D-D)水平及气道重构的影响。方法 纳入2017年1月—2019年12月间收治的COPD患者104例,采用随机数表法分为观察组和对照组,每组各52例。两组均使用噻托溴铵粉吸入剂,观察组在此基础上加用参芪补肺方。比较两组患者疗效,治疗前、治疗12周后,评估患者中医证候积分、实验室指标[NE、D-D、白细胞介素-8(IL-8)]、气道重构相关指标[血管内皮生长因子(VEGF)、神经生长因子(NGF)、基质金属蛋白酶-9(MMP-9)]。结果 (1)治疗12周后,观察组总有效率高于对照组(P<0.05);(2)治疗12周后,两组中医证候积分均低于治疗前(P<0.05),观察组降幅大于对照组(P<0.05);(3)治疗12周后,两组实验室指标(NE、D-D、IL-8)、气道重构相关指标(VEGF、NGF、MMP-9)水平均低于治疗前(P<0.05),观察组降幅大于对照组(P<0.05);(4)两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论 参芪补肺方联合噻托溴铵粉吸入剂治疗COPD安全有效,对患者炎症、高凝血、气道重构均有积极影响。
Objective To explore the effects of Shenqi Bufei Recipe(参芪补肺方)combined with tiotropium bromide powder for inhalation on levels of neutrophil elastase(NE)and D-dimer(D-D)and airway remodeling in patients with chronic pulmonary obstructive disease(COPD).Methods A total of 104 COPD patients admitted between January 2017 and December 2019 were included,and they were divided into observation group and control group according to the random number table method,with 52 cases in each group.The two groups were given tiotropium bromide powder for inhalation,and the observation group was additionally given Shenqi Bufei Recipe on this basis.The efficacy of the two groups was compared.The TCM syndromes scores,laboratory indicators[NE,D-D,interleukin-8(IL-8)],airway remodeling-related indicators[vascular endothelial growth factor(VEGF),nerve growth factor(NGF),matrix metalloproteinase-9(MMP-9)]were evaluated before treatment and after 12 weeks of treatment.Results(1)After 12 weeks of treatment,the total effective rate in the observation group was higher than that in the control group(P<0.05).(2)After 12 weeks of treatment,the TCM syndromes scores in the two groups were lower than those before treatment(P<0.05),and the decreases in the observation group were greater than those in the control group(P<0.05).(3)After 12 weeks of treatment,the levels of laboratory indicators(NE,D-D,IL-8)and airway remodeling-related indicators(VEGF,NGF,MMP-9)in the two groups were lower than those before treatment(P<0.05),and the decreases in the observation group were greater than those in the control group(P<0.05).(4)There were no statistically significant differences in the incidence rates of adverse reactions between the two groups(P>0.05).Conclusion Shenqi Bufei Recipe combined with tiotropium bromide powder for inhalation is safe and effective on treating COPD,and it has positive effects on inflammation,hypercoagulability and airway remodeling.
作者
路志芳
任淑燕
曹秀丽
李新鹏
莘翼翔
张华
崔彩梅
刘晓
樊志惠
方庆娟
LU Zhifang;REN Shuyan;CAO Xiuli;LI Xinpeng;SHEN Yixiang;ZHANG Hua;CUI Caimei;LIU Xiao;FAN Zhihui;FANG Qingjuan(Department of Endoscopy,Zhangjiakou First Hospital,Zhangjiakou 075000,Hebei,China)
出处
《辽宁中医杂志》
CAS
2022年第10期97-100,共4页
Liaoning Journal of Traditional Chinese Medicine
关键词
慢性阻塞性肺病
气道重构
噻托溴铵粉吸入剂
参芪补肺方
chronic obstructive pulmonary disease
airway remodeling
tiotropium bromide powder for inhalation
Shenqi Bufei Recipe(参芪补肺方)
