摘要
目的 观察二黄养血汤联合西医治疗轻中度系统性红斑狼疮的疗效及对患者体液免疫和细胞免疫功能的影响。方法 选取医院于2017年2月—2019年9月收治的疾病活动性指数(SLEDAI)为5~14分的系统性红斑狼疮患者124例,按照奇偶数分组分为两组。对照组给予西医治疗,二黄养血汤组加用二黄养血汤治疗。比较两组证候积分、SLEDAI积分、免疫相关指标、24h蛋白尿、疗效及不良反应。结果 治疗前,两组证候积分、SLEDAI积分比较,差异无统计学意义(P>0.05)。治疗后,两组面部红斑、发热、关节肿痛、瘀斑瘀点、眩晕耳鸣、腰膝酸软、手足心热等积分及SLEDAI积分较治疗前降低(P<0.05)。与对照组比较,二黄养血汤组治疗后的证候积分、SLEDAI积分明显更低(P<0.05)。治疗前,两组24 h蛋白尿、补体、T细胞免疫球蛋白黏蛋白域蛋白-1(Tim-1)、调节性T细胞比较,差异无统计学意义(P>0.05)。治疗后,两组补体C_(3)、补体C_(4)、CD_(4)^(+)CD_(25)^(+)、CD_(40)^(+)T明显更高,24h蛋白尿、Tim-1较治疗前降低(P<0.05)。与对照组比较,二黄养血汤组治疗后的补体C3、补体C4、CD_(4)^(+)CD_(25)^(+)、CD_(40)^(+)T明显更高,24 h蛋白尿、Tim-1明显更低(P<0.05)。二黄养血汤组临床缓解27例,显效和有效30例,总有效率为91.94%高于对照组,差异有统计学意义(P<0.05)。两组在大便偏稀、高血压、血糖升高、感染等不良反应方面比较,差异无统计学意义(P>0.05)。结论 二黄养血汤联合西医治疗轻中度系统性红斑狼疮可提高体液免疫和细胞免疫功能,减轻症状,提高疗效。
Objective To observe the curative effect of Erhuang Yangxue Decoction(二黄养血汤)combined with western medicine on mild to moderate systemic lupus erythematosus and its effect on humoral and cellular immune function.Methods A total of 124 patients with systemic lupus erythematosus with disease activity index(SLEDAI)of 5-14 points in the hospital from February 2017 to September 2019 were selected and divided into two groups according to odd and even numbers.The control group was treated with western medicine,and the Erhuang Yangxue Decoction group was treated with Erhuang Yangxue Decoction.The syndrome score,SLEDAI score,immune related indexes,24 h proteinuria,curative effect and adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in syndrome score or SLEDAI score between the two groups(P>0.05).After treatment,the scores of facial erythema,fever,joint swelling and pain,ecchymosis,dizziness and tinnitus,weakness of waist and knee,heat in palms and soles and SLEDAI in the two groups were lower than those before treatment(P<0.05).Compared with those of the control group,the syndrome score and SLEDAI score of Erhuang Yangxue Decoction group were significantly lower(P<0.05).Before treatment,there was no significant difference in 24 h proteinuria,complement,T cell immunoglobulin mucin domain protein-1(TIM-1)or regulatory T cells between the two groups(P>0.05).After treatment,complement C_(3),complement C_(4),CD_(4)^(+) CD_(25)^(+) and CD_(40)^(+) T were significantly higher in the two groups,and 24 h proteinuria and TIM-1 were lower than those before treatment(P<0.05).Compared with those of the control group,the levels of complement C3,complement C4,CD_(4)^(+) CD_(25)^(+) and CD_(40)^(+) T in Erhuang Yangxue Decoction group were significantly higher,and 24 h proteinuria and TIM-1 were significantly lower(P<0.05).The total effective rate was 91.94%,which was significantly higher than that in the control group(P<0.05).There was no significant difference between the two groups in adverse reactions such as sparse stool,hypertension,elevated blood glucose or infection(P>0.05).Conclusion Erhuang Yangxue Decoction combined with western medicine in the treatment of mild to moderate systemic lupus erythematosus can improve humoral and cellular immune function,reduce symptoms and improve the curative effect.
作者
欧阳孔亮
王伟彪
OUYANG Kongliang;WANG Weibiao(First Clinical Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China;School of Basic Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,Guangdong,China)
出处
《辽宁中医杂志》
CAS
2022年第10期140-143,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
广东省科研基金项目(815012240)。
关键词
二黄养血汤
系统性红斑狼疮
疗效
体液免疫
细胞免疫功能
Erhuang Yangxue Decoction(二黄养血汤)
systemic lupus erythematosus
curative effect
humoral immunity
cellular immune function
