摘要
目的:分析人绝经期促性腺激素(hMG)联合人绒毛膜促性腺激素(HCG)治疗不孕症促排卵效果及对子宫内膜厚度和妊娠的影响。方法:以2018年7月-2021年7月在本院进行治疗的不孕症患者110例为研究对象,按照就诊编号采用随机数字表法分为观察组及对照组各55例。对照组给予hMG治疗,观察组给予hMG联合HCG治疗,均治疗8周期。比较两组治疗效果、卵泡成熟以及hMG用药剂量、妊娠情况、优势卵泡最大直径、不良反应。结果:观察组治疗总有效率(96.4%)高于对照组(83.6%),血清孕酮、卵泡刺激素、睾酮均低于对照组,黄体生成素、雌二醇水平高于对照组(均P<0.05);随着治疗的延长,两组子宫内膜厚度均升高且观察组高于对照组(P<0.05);观察组卵泡成熟时间(11.1±1.8 d)以及hMG用药剂量(6.8±1.2支)均小于对照组(12.5±1.0 d、10.0±1.0支),两组优势卵泡最大直径较治疗前明显增大且观察组(18.6±2.4 mm)高于对照组(16.4±2.2 mm)(均P<0.05);观察组妊娠率(78.2%)高于对照组(60.0%),早孕流产(0)以及多卵泡发育(0)情况低于对照组(9.1%、7.3%)(均P<0.05)。结论:hMG联合HCG治疗不孕促排卵效果提高,子宫内膜厚度以及妊娠情况均得到显著改善。
Objective:To analyze the ovulation induction effect of human menopausal gonadotropin(hMG)combined with human chorionic gonadotropin(HCG)for treating infertility patients,and to study its influence on the endometrial thickness and pregnancy status of these patients.Methods:110 infertility patients were selected as the research objects from July 2018 to July 2021.According to the visit number,these patients were divided into observation group and control group(55 patients in each group).The patients in the control group were treated with hMG for 8 cycles,and the patients in the observation group were treated with hMG combined with HCG for 8 cycles.The therapeutic effect,follicle maturation rate,hMG dose,pregnancy status,maximum diameter of dominant follicle,and adverse reactions of the patients were compared between the two groups.Results:After treatment,the total effective rate(96.4%)of the patients in the observation group was significantly higher than that(83.6%)of the patients in the control group.The levels of serum progesterone,follicle-stimulating hormone,and testosterone of the patients in the observation group were significantly lower than those of the patients in the control group,but the levels of luteinizing hormone and estradiol of the patients in the observation group were significantly higher(all P<0.05).With the prolong of treatment,the endometrial thickness of the patients in both groups had increased significantly,and which of the patients in the observation group was significantly higher than that of the patients in the control group(P<0.05).The follicle maturation time(11.1±1.8 d)and the dose of hMG(6.8±1.2 vials)of the patients in the observation group were significantly lower than those(12.5±1.0 d and 10.0±1.0 vials)of the patients in the control group.The maximum diameter of dominant follicles of the patients in both groups had increased significantly after treatment,and which(18.6±2.4mm)of the patients in the observation group was significantly higher than that(16.4±2.2mm)of the patients in the control group(P<0.05).The pregnancy rate(78.2%)of the patients in the observation group was significantly higher than that(60.0%)of the patients in the control group,the early pregnancy abortion rate(0)and multiple follicle development rate(0)of the patients in the observation group were significantly lower than those(9.1%and 7.3%)of the patients in the control group(all P<0.05).Conclusion:HMG combined with HCG for treating the infertile patients has higher effect of ovulation induction,and which can improve the endometrial thickness and pregnancy condition significantly.
作者
吴兴花
林凯
黄庆慧
WU Xinghua;LIN Kai;HUANG Qinghui(Ningde City Hospital Affiliated to Ningde Normal University,Ningde,Fujian Province,352100)
出处
《中国计划生育学杂志》
2023年第1期47-51,共5页
Chinese Journal of Family Planning
关键词
不孕症
促排卵
人绝经期促性腺激素
人绒毛膜促性腺激素
性激素
子宫内膜
妊娠
不良反应
Infertile
Ovulation induction
Human menopausal gonadotropin
Human chorionic gonadotropin
Sex hormones
Endometrial
Pregnancy
Adverse reaction
