摘要
目的:探究宫腔镜电切术联合左炔诺孕酮宫内缓释系统治疗子宫内膜息肉疗效及对患者雌孕激素受体表达、炎性因子的影响。方法:选取本院2018年1月-2020年1月收治的子宫内膜息肉患者142例,随机分为观察组和对照组各71例。两组均给予宫腔镜电切术,观察组术后联合宫腔放置左炔诺孕酮宫内缓释系统。比较两组治疗效果和治疗前后雌激素受体(ER)、孕激素受体(PR)及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、C反应蛋白(CRP)表达差异。结果:两组术后6个月时月经失血图评分、月经周期、子宫内膜厚度均低于术前,血红蛋白水平高于术前,且观察组变化幅度大于对照组;PR、ER表达水平低于术前,观察组PR(0.94±0.43)、ER(1.66±0.60)表达水平低于对照组(1.50±0.62、1.94±0.74);两组宫腔灌洗液炎性因子IL-6、TNF-α、IFN-γ、CRP水平均低于术前,且观察组低于对照组(均P<0.05)。复发率观察组(2例,2.8%)低于对照组(11例,15.5%)(P<0.05)。结论:宫腔镜电切术联合左炔诺孕酮宫内缓释系统治疗子宫内膜息肉可有效调节患者术后雌孕激素受体表达,降低炎性因子水平,减少术后复发。
Objective:To explore the efficacy of hysteroscopic electrocision combined with progesterone intrauterine system(IUS)for treating patients with endometrial polyps,and to study its influence on the levels of estrogen and progesterone receptor expressions and the inflammatory factors of these patients.Methods:A total of 142 patients with endometrial polyps were selected and randomly divided into two groups(71 cases in each group)from January 2018 to January 2020.The patients in the control group were given hysteroscopic resection of endometrial polyps,and the patients in the observation group were given hysteroscopic resection of endometrial polyps and IUS inserted.The different levels of estrogen receptor(ER),progesterone receptor(PR),and the levels of inflammatory factors,such as interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),C-reactive protein(CRP)of the patients before and after treatment were compared between the two groups.Results:In the sixth month after surgery,the score of menstrual blood loss map,the menstrual cycle,and the endometrial thickness of the patients in both groups had decreases significantly,the hemoglobin level of the patients in both groups had increases significantly,and the change ranges of which of the patients in the observation group were significantly more than those of the patients in the control group.The expression levels of PR and ER(0.94±0.43 and 1.66±0.60)of the patients in the observation group were significantly lower than those(1.50±0.62 and 1.94±0.74)of the patients in the control group.The levels of inflammatory factors,such as IL-6,TNF-α,IFN-γ,and CRP of the patients in both groups after surgery had decreased significantly,and which of the patients in the observation group were significantly lower than those of the patients in the control group(all P<0.05).The recurrence rate(2cases,2.8%)of the patients in the observation group was significantly lower than that(11cases,15.5%)of the patients in the control group(P<0.05).Conclusion:Hysteroscopic resection combined with IUS for treating endometrial polyps of the patients can effectively regulate the expression of their estrogen and progesterone receptors after surgery,and can reduce their level of inflammatory factors and their recurrence of endometrial polyps.
作者
杨梅
杨华
王彤
YANG Mei;YANG Hua;WANG Tong(Jiangyou People’s Hospital,Jiangyou,Sichuan Province,621700)
出处
《中国计划生育学杂志》
2023年第1期60-63,68,共5页
Chinese Journal of Family Planning
关键词
子宫内膜息肉
宫腔镜电切术
左炔诺孕酮宫内缓释系统
雌激素受体
孕激素受体
炎性因子
复发
Endometrial polyps
Hysteroscopic electrocision
Progesterone intrauterine system
Estrogen receptor
Progesterone receptor
Inflammatory factor
Recurrence
