摘要
目的:观察外科切削联合5-氨基酮戊酸光动力治疗不宜或不愿行手术治疗的皮肤恶性肿瘤的疗效与不良反应。方法:59例患者根据肿瘤情况及患者意愿分为两组。治疗组(28例)应用外科切削联合5-氨基酮戊酸光动力治疗皮肤恶性肿瘤;对照组(31例)单纯采用手术切除治疗。于1年后观察疗效及不良反应。结果:治疗组、对照组治疗皮肤恶性肿瘤的有效率分别为96.43%、93.55%,差异无统计学意义(P=0.563),明显不良反应发生率分别为7.14%、12.9%,差异无统计学意义(P=0.673)。治疗组皮损短径、长径分别为(0.91±0.60)cm、(1.18±0.79)cm,对照组短径、长径分别为(1.89±1.13)cm、(2.46±1.63)cm,两组皮损短径、长径比较,差异有统计学意义(P均<0.001)。治疗组、对照组肿瘤位于特殊部位者分别占78.57%、16.13%,差异有统计学意义(P<0.001)。结论:外科切削联合5-氨基酮戊酸光动力治疗皮肤恶性肿瘤的疗效与不良反应发生率与单纯外科手术切除相近,可作为治疗特殊部位或者特殊人群皮肤恶性肿瘤的方法之一,且更适合小面积皮肤恶性肿瘤的治疗。肿瘤的大小、部位是患者和医师选择治疗方式的影响因素之一。
Objective:To evaluate the efficacy and adverse reaction of surgical cutting combined with 5-aminolevulinic acid photodynamic therapy in the treatment of skin cancer for those unsuitable or unwilling to undergo surgical treatment.Methods:A total of 59 patients with skin cancer were divided into two groups according to their tumor status and wishes.The treatment group(n=28)was treated with surgical cutting combined with 5-aminolevulinic acid photodynamic therapy.The control group(n=31)was treated with surgical excision.The efficacy and adverse reaction were evaluated one year after the treatment.Results:The efficacy of the treatment group and control group were 96.43%and 93.55%respectively,with no significant difference(P=0.563).The incidence of notable adverse reaction in the treatment group and control group were 7.14%and 12.9%,respectively,with no significant difference(P=0.673).The short diameter and long diameter of the tumors in the treatment group were(0.91±0.60)cm and(1.18±0.79)cm,respectively,which was significantly lower than that in the control group[(1.89±1.13)cm and(2.46±1.63)cm,respectively],with statistical significance(P<0.001).The cancers in the treatment group and the control group located in special sites accounted for 78.57%and 16.13%,respectively,with statistical significance(P<0.001).Conclusion:The efficacy and incidence of notable adverse reaction of surgical cutting combined with photodynamic treatment of skin cancer are similar to that of surgical excision,it can be used as one of the options to treat skin cancer of special sites or populations,and may be more suitable for the treatment of small area skin cancer.The size and location of a skin cancer is one of influence factors for patients and doctors to choose treatment methods.
作者
卢井发
黄雪娇
闫越颖
曾招林
万春雷
LU Jing-fa;HUANG Xue-jiao;YAN Yue-ying;ZENG Zhao-lin;WAN Chun-lei(Department of Dermatology,The First Affiliated Hospital of Gannan Medical University;Department of Intervention Treatment,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000;Department of Dermatology,Heze Municipal Hospital,Heze,Shandong 274000)
出处
《赣南医学院学报》
2022年第11期1174-1177,1215,共5页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
赣州市指导性科技计划项目(GZ2018ZSF092)。
