摘要
牙周炎与糖尿病均为患病率较高的慢性疾病,且两者关系密切:一方面糖尿病是牙周炎的危险因素,另一方面牙周炎对糖尿病的血糖控制有负面影响,两者的关联是近年来研究的热点。本文从牙周炎对糖尿病的影响入手,总结传统的牙周袋-血液循环途径的机制,并就近年来提出的口腔-肠道途径在其中的作用进行综述。另一方面,关于糖尿病对牙周炎的影响,本文从口腔菌群的改变、炎症因子和脂肪因子水平异常、氧化应激、成骨-破骨平衡失调和晚期糖基化终末产物积聚等方面总结近年来的新发现,以期为进一步研究两者之间的关联机制梳理思路。
Periodontitis and diabetes mellitus are both chronic diseases with a rather high prevalence and they are closely associated with each other. On one hand, diabetes mellitus poses as a risk factor for periodontitis. On the other hand, periodontitis has a negative impact on glucose control in diabetic patients. The two-way relationship has aroused a lot of research interest in recent years. Herein, approaching the issue by looking at the effect of periodontitis on diabetes,we summarized the mechanism of the traditional periodontal pocket-blood circulation pathway and reviewed the role of the oral-gut axis in the mechanism, which has been proposed in recent years. In addition, regarding the impact of diabetes on periodontitis, we summarized new findings concerning changes in oral microbiota, abnormal levels of cytokines and adipokines, oxidative stress, unbalanced osteogenic and osteoclastic activities, and the accumulation of advanced glycation end-products. We hope this paper will be helpful for further studies on the mechanism of association between periodontitis and diabetes.
作者
李丽丽
谢晓婷
吴贇
闫福华
LI Li-li;XIE Xiao-ting;WU Yun;YAN Fu-hua(Department of Periodontology,Nangjing Stomatological Hospital,Medical School of Nanjing University,Nanjing 210008,China;The Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China;Stomatological Center,First Affiliated Hospital,Fujian Medical University,Fuzhou 350004,China)
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2023年第1期71-76,共6页
Journal of Sichuan University(Medical Sciences)
基金
江苏省自然科学基金(No.BK20220198)
南京口腔疾病临床医学研究中心项目(No.2019060009)资助。
关键词
糖尿病
牙周炎
系统性炎症
肠道菌群
Diabetes
Periodontitis
Systemic inflammation
Gut microbiota
