摘要
目的 分析白细胞介素(IL)-6、IL-8、IL-18、血管内皮生长因子(VEGF)诊断活动性肺结核的价值。方法 选取2019年6月至2021年6月兰州市肺科医院和甘肃省人民医院收治的80例活动性肺结核患者作为活动性肺结核组,73例非活动性肺结核患者作为非活动性肺结核组,另选取同期80例健康体检者作为对照组,检测并比较3组受试者血清IL-6、IL-8、IL-18、VEGF水平,以及活动性肺结核组内有、无胸腔积液组和有、无空洞组IL-6、IL-8、IL-18、VEGF水平。结果 活动性肺结核组和非活动性肺结核组血清IL-6、IL-8、IL-18、VEGF水平均明显高于对照组,且活动性肺结核组高于非活动性肺结核组,差异均有统计学意义(P<0.05);活动性肺结核组内有胸腔积液组血清IL-6、IL-8、IL-18、VEGF水平均明显高于无胸腔积液组,有空洞组血清IL-6、IL-8、IL-18、VEGF水平均明显高于无空洞组,差异均有统计学意义(P<0.05)。结论 在活动性肺结核诊断中,IL-6、IL-8、IL-18、VEGF均可作为生物学标志物推广使用。
Objective To analyze the value of interleukin-6(IL-6),interleukin-8(IL-8),interleukin-18(IL-18),vascular endothelial growth factor(VEGF) in identifying active tuberculosis.Methods A total of 80 patients with active pulmonary tuberculosis received in Lanzhou Lung Hospital and Provincial People′s Hospital from June 2019 to June 2021 were selected as the active pulmonary tuberculosis group, 73 patients with inactive pulmonary tuberculosis were selected as the inactive pulmonary tuberculosis group, and 80 healthy people in the same period were selected as the control group.The serum IL-6,IL-8,IL-18 and VEGF of the three groups were measured and compared, and the differences of IL-6,IL-8,IL-18 and VEGF in the active pulmonary tuberculosis group with or without pleural effusion and in the patients with or without cavities were compared.Results The serum levels of IL-6,IL-8,IL-18 and VEGF in the active and inactive pulmonary tuberculosis groups were significantly higher than those in the control group, and the levels of IL-6,IL-18 and VEGF in the active pulmonary tuberculosis group were significantly higher than those in the inactive pulmonary tuberculosis group(P<0.05).The levels of IL-6,IL-8,IL-18 and VEGF in patients with pleural effusion in active pulmonary tuberculosis group were significantly higher than those in patients without pleural effusion, and the levels of IL-6,IL-8,IL-18 and VEGF in patients with cavities were significantly higher than those in patients without cavities(P<0.05).Conclusion IL-6,IL-8,IL-18 and VEGF can be used as biological markers in the differential diagnosis of active pulmonary tuberculosis.
作者
陈玉芊
王世军
王欣
徐修礼
CHEN Yuqian;WANG Shijun;WANG Xin;XU Xiuli(Greater Xi′an Area Medical Diagnostic Lab Center,Xi′an,Shaanxi 710116,China;Department of Clinical Laboratory,Lanzhou Lung Hospital,Lanzhou,Gansu 730046,China;Laboratory Center,Gansu Provincial People′s Hospital,Lanzhou,Gansu 730013,China)
出处
《检验医学与临床》
CAS
2023年第2期224-227,共4页
Laboratory Medicine and Clinic
