摘要
目的探讨参附汤在脓毒症休克患者中的临床应用效果。方法选取2020年1月—2021年12月期间江苏省宿迁市中医院收治的62例脓毒症休克患者为研究对象,按照随机数法分为对照组、观察组,各31例。其中对照组采用常规西医治疗,观察组给予参附汤治疗。对两组患者治疗前后的氧代谢指标(Lac、ScvO_(2))水平、尿量与血清炎症指标(血清白细胞介素6、超敏C反应蛋白、肿瘤坏死因子α)进行监测,同时进行APACHE-Ⅱ评分,并比较两组患者临床治疗有效性。结果治疗前,两组患者氧代谢指标水平及尿量对比差异无统计学意义(P>0.05),治疗后,观察组患者Lac、尿量、ScvO_(2)水平均较对照组更优,差异有统计学意义(P<0.05)。观察组总有效率93.55%高于对照组67.74%,差异有统计学意义(χ^(2)=6.613,P<0.05)。治疗前,两组APACHE-Ⅱ评分差异无统计学意义(P>0.05),而治疗后观察组APACHE-Ⅱ评分、IL-6、hs-CRP、TNF-α水平均优于对照组,差异有统计学意义(P<0.05)。结论参附汤对脓毒症休克患者的治疗效果非常显著,可有效改善患者氧代谢指标,减轻炎症反应,提高临床治疗有效性。
Objective To investigate the clinical effect of Shenfu decoction in patients with septic shock.Methods From January 2020 to December 2021,62 patients with septic shock admitted to Suqian Hospital of Traditional Chinese Medicine in Jiangsu Province were selected as the research object and divided into control group and observation group according to random number table,with 31 patients in each group.Among them,the control group was treated with conventional Western medicine,and the observation group was given Shenfu decoction.The levels of oxygen metabolism indexes(Lac,ScvO_(2)),urine volume and serum inflammatory indicators(serum interleukin 6,ultrasensitive C-reactive protein,tumor necrosis factorα)were monitored in both groups before and after treatment.The APACHE-Ⅱscore was also evaluated and the effectiveness of clinical treatment was compared between the two groups.Results Before treatment,there was no statistically significant difference in the levels of oxygen metabolism indexes and urine volume between the two groups of patients(P>0.05).After treatment,Lac,urine volume and ScvO_(2)levels of patients in the observation group were better than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of 93.55%in the observation group was higher than that of 67.74%in the control group,and the difference was statistically significant(χ^(2)=6.613,P<0.05).Before treatment,there was no statistically significant difference in APACHE-Ⅱscore between the two groups(P>0.05),while after treatment,APACHE-II score,IL-6,hs-CRP and TNF-αlevels in the observation group were better than those in the control group,and the difference was statistically significant(P<0.05).Conclusion The therapeutic effect of Shenfu decoction on patients with septic shock is very significant,which can effectively improve the oxygen metabolic index of patients,reduce the inflammatory response and improve the effectiveness of clinical treatment.
作者
陆敬宪
LU Jingxian(Department of Critical Care Medicine,Suqian City Hospital of Traditional Chinese Medicine,Suqian,Jiangsu Province,223800 China)
出处
《系统医学》
2022年第20期53-57,共5页
Systems Medicine
关键词
参附汤
脓毒症休克
氧代谢指标
治疗效果
炎症反应
衰竭症状
Shenfu decoction
Septic shock
Oxygen metabolic index
Therapeutic effect
Inflammatory response
Symptoms of exhaustion
