摘要
结核病(tuberculosis,TB),特别是儿童结核病,仍是影响全球健康的重要因素。由于传统的结核病诊断技术灵敏度、特异度较差,结核病病例常因为无法得到准确、及时的诊断而被延误治疗。儿童结核病病灶含菌量低,且患儿常无法咳出痰,因此,儿童结核病诊断较成人结核病诊断更具有挑战性。脂阿拉伯甘露聚糖(lipoarabinomannan,LAM)是结核分枝杆菌(Mycobacterium tuberculosis,MTB)细胞壁上的特异性抗原,可以在结核患者的尿液标本中检测到,尿LAM检测有助于快速、准确地诊断结核病。本综述旨在总结LAM检测用于儿童结核病诊断的研究进展。
Tuberculosis(TB),especially pediatric TB,remains an important global health concern.Due to poor sensitivity and specificity of traditional TB diagnostic techniques,TB cases cannot be accurately and timely diagnosed,leading to delayed treatment for patients.The low bacterial load and inability to cough up sputum in children make TB diagnosis more challenging in children than in adult.Lipoarabinomannan(LAM),an antigen on the cell wall of Mycobacterium tuberculosis(MTB),is found in the urine of TB patients,and detection of urine LAM is helpful to diagnose TB quickly and accurately.Herein,the research progress of LAM assay for TB diagnosis in children is reviewed.
作者
王尉蓉
范雨鑫
孔璟
刘玫肖
陈晶晶
高利
吴新雅
柳爱华
宝福凯
WANG Wei-rong;FAN Yu-xin;KONG Jing;LIU Mei-xiao;CHEN Jing-jing;GAO Li;WU Xin-ya;LIU Ai-hua;BAO Fu-kai(Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities,Kunming Medical University,Kunming 650500,Yunnan,China;The First Clinical College,Kunming Medical University,Kunming 650500,Yunnan,China;Department of Microbiology and Immunology,Kunming Medical University,Kunming 650500,Yunnan,China;Department of Biochemistry and Molecular Biology,Kunming Medical University,Kunming 650500,Yunnan,China)
出处
《生命科学研究》
CAS
CSCD
2022年第6期522-527,共6页
Life Science Research
基金
云南省自然科学基金资助项目[2019FE001(-002)]
国家自然科学基金资助项目(32060180,81860644,81560596,31560051)
云南省教育厅科学研究基金项目(2022Y208)。
