摘要
砷是一种有毒类金属,已被确定为人类致癌物,砷中毒会造成人体多种健康问题。砷可以分为无机砷和有机砷,一般认为无机砷毒性大于有机砷。砷脂属于有机砷,广泛存在于海洋生物组织中。之前的研究认为砷脂毒性极低,但近年来随着科学技术的进步与发展,对砷脂的研究越来越深入,砷脂的形态分析和毒性评价也逐步成为热点。目前已知的砷脂主要包括含砷脂肪酸、含砷碳氢化合物和含砷磷脂3种形态,且不同形态之间毒性各不相同。但由于其形态结构复杂、生物利用度低、含量低以及提取和检测难度高等原因,砷脂毒性作用机制尚不明确。因此,本文综述了海洋生物中砷脂主要形态的分析方法和毒性评价的最新研究进展,以期为进一步阐明砷脂的形态、毒性以及对人类健康的风险评估提供参考。
Arsenic is a poisonous semi-metal(metalloid)and has been identified as a human carcinogen.Arsenic poisoning can cause a variety of health damage to the human body.Arsenic can exist in both inorganic and organic forms.It is generally considered that inorganic arsenic is more toxic than organic arsenic.Arsenolipids are organic arsenic and widely exist in tissues of marine organisms.Arseniolipids have been previously thought to be extremely low toxic.With the progress and development of science and technology in recent years,intensive research has been conducted on arsenolipids,and the speciation analysis and toxicity evaluation of arsenolipids have gradually become a hot spot.At present,there are three known species of arsenolipids,namely arsenic-containing fatty acids(AsFAs),arsenic-containing hydrocarbons(AsHCs)and arsenic-containing phospholipids(AsPLs),which differ in their toxicity.However,due to the complex speciation pattern,low bioavailability and low content of arsenolipids,and the difficulty to extract and detect them,the mechanism of arsenolipid toxicity remain unclear.Therefore,this paper reviews the latest progress in the methods for speciation analysis and toxicity evaluation of arsenolipids in marine organisms,with the aim to provide an inspiration for further elucidating the speciation,toxicity,and human health risk of arsenolipids.
作者
陈佳佳
钟映雄
周雪巍
李瑞
陈建平
刘晓菲
贾学静
宋兵兵
钟赛意
CHEN Jiajia;ZHONG Yingxiong;ZHOU Xuewei;LI Rui;CHEN Jianping;LIU Xiaofei;JIA Xuejing;SONG Bingbing;ZHONG Saiyi(Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,Guangdong Province Engineering Laboratory for Marine Biological Products,Guangdong Provincial Engineering Technology Research Center of Seafood,College of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524088,China;Shenzhen Research Institute,Guangdong Ocean University,Shenzhen 518108,China;Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian 116034,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2023年第1期277-284,共8页
Food Science
基金
国家自然科学基金面上项目(31972163)
“十三五”国家重点研发计划项目(2020YFD0901101)
广东省重点领域研发计划项目(2020B1111030004)
广东省高校科技创新团队项目(2021KCXTD021)。
关键词
海洋生物
砷脂
形态分析
毒性评价
marine organisms
arsenolipids
speciation analysis
toxicity evaluation
