摘要
溃疡性结肠炎(UC)是以腹痛腹泻和黏液脓血便为主要临床表现、以结直肠黏膜及黏膜下层炎症损伤为主要病理改变的慢性非特异性消化道疾病。随着人们生活习惯和饮食结构的改变,UC的发病率及癌变率在世界范围内呈快速上升趋势,严重降低患者生活质量、造成巨大社会负担。迄今,其发病机制尚未阐明,西医临床中常用氨基水杨酸类、糖皮质激素和免疫抑制剂等药物缓解症状,然而长期使用会导致疗效降低、不良反应增多等问题。基于中医药多环节、多层次、多靶点的整合调节优势,中医药通过抑制炎症反应、缓解氧化应激、保护肠黏膜屏障、调节肠道菌群失衡等作用机制治疗UC的研究越来越多。鉴于此,笔者通过查阅近10年相关文献,综述了中药活性成分、单味中药提取物、中药药对、经典复方、中药联用化学药治疗UC的作用及机制,以期为寻求有效药物提供参考。
Ulcerative colitis(UC)is a chronic non-specific digestive disease with abdominal pain,diarrhea,and blood and mucus in stool as the main clinical manifestations and inflammatory injury of colorectal mucosa and submucosa as the main pathological changes.With the change in living habits and dietary structure of people,the incidence and cancer morbidity in UC are rising rapidly all over the world,which has seriously reduced the quality of life and caused a huge social burden.Till now,the pathogenesis has not been elucidated.In western medicine,aminosalicylates,corticosteroids,and immunosuppressors are commonly used to relieve symptoms.However,the long-term application will lead to problems such as decreased efficacy and increased adverse reactions.There are more studies of traditional Chinese medicine(TCM)in the treatment of UC by reducing the inflammatory response,alleviating oxidative stress,protecting the intestinal mucosal barrier,and regulating intestinal microecological imbalance by virtue of the advantages of integrated regulation based on multiple links,levels,and targets.In view of this,the present study reviewed the effect and mechanism of active ingredients of TCM,TCM extracts,TCM pairs,classic TCM compounds,and TCM combined with chemical agents in the treatment of UC based on relevant research articles in recent 10 years to provide references for seeking effective drugs.
作者
王春霞
葛俊李
李芳
赵鲲鹏
邵士俊
杨扶德
冯金梁
WANG Chunxia;GE Junli;LI Fang;ZHAO Kunpeng;SHAO Shijun;YANG Fude;FENG Jinliang(College of Pharmacy,Gansu University of Chinese Medicine,Lanzhou 730000,China;Clinical College of Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China;Gansu Kangle Pharmaceutical Co.Ltd.,Lanzhou 730300,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第2期270-282,共13页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重点研发计划项目(2018YFC1706305)
2021年甘肃省高等学校产业支撑引导项目(2021CYZC-40)
甘肃省科技小巨人企业培育计划项目(17CXIJA084)
2018年度甘肃省委组织部人才发展专项资金项目(甘组[2018]23号)
2018年兰州市人才创新创业科技计划项目(2017-RC-112)。
关键词
溃疡性结肠炎
中药活性成分
单味中药提取物
中药药对
经典复方
中药联用化学药
作用机制
ulcerative colitis
active ingredients of traditional Chinese medicine(TCM)
TCM extracts
TCM pairs
classic TCM compounds
combined use of TCM with chemical agents
mechanism
