摘要
目的观察保妇康栓联合聚甲酚磺醛溶液治疗人乳头瘤病毒(HPV)感染合并宫颈炎的疗效。方法将80例HPV感染合并宫颈炎患者随机分为联合组与对照组各40例。对照组予以聚甲酚磺醛溶液治疗,联合组在对照组治疗基础上予以保妇康栓联合治疗。比较两组患者临床疗效、病毒转阴情况、临床症状改善情况、炎症水平[肿瘤坏死因子-(TNF-)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)]变化以及用药安全性。结果治疗后,联合组患者治疗总有效率及HPV转阴率均高于对照组(P<0.05);两组患者临床症状评分、hs-CRP、IL-6、TNF-水平及HPV病毒载量均较治疗前降低,且联合组低于对照组(P<0.05);治疗期间两组患者均未发生严重不良反应(P>0.05)。结论保妇康栓联合聚甲酚磺醛溶液治疗HPV感染合并宫颈炎的临床效果显著,可有效缓解患者相关症状,降低病毒载量,提升HPV转阴率,同时能抑制机体炎症水平,且不会增加用药风险,安全性较高。
Objective To observe the curative effect of Baofukang Suppository combined with policresulen solution on human papilloma virus(HPV)infection combined with cervicitis.Methods A total of 80 patients with HPV infection and cervicitis were randomly divided into combination group and control group,40 cases in each group.Control group was treated with policresulen solution,while combination group was additionally treated with Baofukang suppository.The clinical curative effect,negative conversion of viruses,improvement of clinical symptoms,changes of inflammation indexes[tumor necrosis factor-(TNF-),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)]and medication safety were compared between the two groups.Results After treatment,total response rate of treatment and negative conversion rate of HPV in combination group were higher than those in control group(P<0.05);scores of clinical symptoms,levels of hs-CRP,IL-6 and TNF-,and HPV load were all decreased in both groups,which were lower in combination group than control group(P<0.05);during treatment,there were no serious adverse reactions in either group(P>0.05).Conclusion The clinical curative effect of Baofukang Suppository combined with policresulen solution is significant on HPV infection combined with cervicitis,which can effectively relieve related symptoms,reduce viral load,increase negative conversion rate of HPV,inhibit inflammation level and will not increase medication risk with high safety.
作者
刘袁静
陈静
陈毛兰
韩建香
LIU Yuan-jing;CHEN Jing;CHEN Mao-lan;HAN Jian-xiang(Nanjing Tongren Hospital Affiliated to Southeast University School of Medicine,Nanjing 211102)
出处
《湖北中医药大学学报》
2022年第6期74-76,共3页
Journal of Hubei University of Chinese Medicine
基金
江苏省科技社会发展面上项目(项目编号:BE2015006)
东南大学医学院附属南京同仁医院项目(项目编号:2021E007)。
关键词
宫颈炎
人乳头瘤病毒
保妇康栓
聚甲酚磺醛溶液
Cervicitis
Human papilloma virus
Baofukang Suppository
Policresulen solution
