摘要
目的 基于数据挖掘软件中医传承辅助平台(V2.5)及Cytoscape 3.7.2分析周彩云教授治疗急性痛风性关节炎用药规律。方法 采集2019年9月至2021年12月中国中医科学院西苑医院周彩云教授门诊接诊的急性痛风性关节炎患者病例数据,采用关联规则,复杂系统熵聚类方法,进行数据挖掘及网络可视化分析,总结中药频次、归经、性味及药对组合,挖掘核心处方,探讨其用药规律。结果 纳入130张处方,共77味中药,高频药物为葛根、马齿苋、金钱草、绵萆薢、豨莶草、车前草、海金沙、车前子、金银花、黄柏、冬瓜皮。药物四气以寒为主,五味以甘为首,归经以肝、肾经为主,频次较高的药物组合为葛根,马齿苋;葛根,马齿苋,金钱草等。挖掘新处方4个,分别为浙贝母,冬瓜皮,海螵蛸,红花,菊花;茵陈,炒白术,鸡骨草,郁金;金钱草,牛膝,黄芪,石斛,远志;防己,猪苓,威灵仙,玉米须,生地黄。结论 周彩云教授治疗急性痛风性关节炎从“湿毒”立论,以清热利湿、解毒通络为主要治法,兼以补益肝肾、调养脾胃。
Objective To analyze the medication rule of Professor Zhou Caiyun in the treatment of acute gouty arthritis based on data mining software Traditional Chinese Medicine Inheritance Assistance Platform(V2.5) and Cytoscape 3.7.2.Methods Data of patients with acute gouty arthritis treated by Professor Zhou Caiyun in the outpatient department of Xiyuan Hospital,China Academy of Chinese Medical Sciences from September,2019 to December,2021 were collected.Using association rules and complex system entropy clustering method,data mining and network visualization analysis were carried out to summarize the frequency,channel tropism,nature,flavour,and couplet medicines combination of traditional Chinese medicine,explore the core prescription,and explore the medication rule.Results A total of 77 traditional Chinese medicines were included in 130 prescriptions,among which the most frequently used medicines were Puerariae Lobatae Radix,Portulacae Herba,Lysimachiae Herba,Dioscoreae Spongiosae Rhizoma,Siegesbeckiae Herba,Plantaginis Herba,Lygodii Spora,Plantaginis Semen,Lonicerae Japonicae Flos,Phellodendri Chinensis Cortex,and Benincasae Exocarpium.The four nature of drugs were mainly cold,the five flavours were mainly sweet,and the channel tropism was mainly liver and kidney channels.The drug combinations with high frequency were Puerariae Lobatae Radix and Portulacae Herba;Puerariae Lobatae Radix,Portulacae Herba,and Lysimachiae Herba,etc.Four new prescriptions were dug,which were Fritillariae Thunbergii Bulbus,Benincasae Exocarpium,Sepiae Endoconcha,Carthami Flos,and Chrysanthemi Flos;Artemisiae Scopariae Herba,Stir-Atractylodis Macrocephalae Rhizoma,Abri Herba,and Curcumae Radix;Lysimachiae Herba,Achyranthis Bidentatae Radix,Astragali Radix,Dendrobii Caulis,and Polygalae Radix;Stephaniae Tetrandrae Radix,Polyporus,Clematidis Radix Et Rhizoma,corn beard,and Rehmanniae Radix.Conclusion Professor Zhou Caiyun’s treatment of acute gout arthritis is based on the theory of “dampness toxin”.The main treatment methods are clearing heat and promoting diuresis,detoxifying for removing obstruction in collaterals,and tonifying liver and kidney as well as nourishing spleen and stomach.
作者
陈一帆
周彩云
王鑫
CHEN Yifan;ZHOU Caiyun;WANG Xin(Department of Rheumatism,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)
出处
《中国医药导报》
CAS
2023年第2期126-129,134,共5页
China Medical Herald
基金
国家自然科学基金青年科学基金项目(61805286)
国家重点研发计划课题(2017YFC1700301)
北京中医药薪火相传“3+3”工程项目(2016-SZ-C-63)
中国中医科学院科技创新工程项目(CI2021A01514)。
关键词
痛风
湿毒
数据挖掘
用药规律
周彩云
Gout
Dampness toxin
Data mining
Medication rule
Zhou Caiyun
