摘要
葛根Pueraria lobata是药食同源中药,具有多种功效。现代药学研究表明异黄酮类是葛根的主要活性成分,已经分离到53个葛根异黄酮化合物,包括葛根素、大豆苷元、大豆苷、葛根素木糖苷、3’-羟基葛根素、染料木素、染料木苷、鹰嘴豆芽素A、芒柄花素、毛蕊异黄酮等,具有解酒护肝、降血糖、调血脂、缓解绝经性骨质疏松、抗肿瘤、心脏保护、抗炎、神经保护、抗氧化等药理作用。对葛根异黄酮类的药理作用进行综述,以期为该类成分的进一步研究和新药研发提供参考。
Pueraria lobata is a homology of medicine and food with multiple effects.Modern pharmacological investigations demonstrate that isoflavones are the main active components of P.lobata.And it was reported that 53 isoflavone compounds had been isolated from the root of P.lobata,including puerarin,daidzein,daidzin,puerarin xyloside,3’-hydroxypuerarin,genistein,genistin,biochanin A,formononetin,calycosin,and so on.They have pharmacological effects such as antialcoholism,liver protection,hypoglycemia,lipid-lowering,menopausal osteoporosis relief,anti-tumor,heart protection,anti-inflammatory,neuroprotection and anti-oxidation.This paper reviews the pharmacological effects of isoflavones from P.lobata,which provides reference for further research and new drug development of this kind of components.
作者
陈凯
魏平慧
史琳
CHEN Kai;WEI Pinghui;SHI Lin(College of Life Science,Shangrao Normal University,Shangrao Innovation Institute of Agricultural Technology,Shangrao 334001,China;College of Food Science,Shenyang Agriculture University,Shenyang 110866)
出处
《药物评价研究》
CAS
2022年第12期2602-2610,共9页
Drug Evaluation Research
基金
江西省农业农村厅现代农业产业技术体系建设专项(JXARS-16)。
关键词
葛根
异黄酮
药理作用
葛根素
大豆苷元、染料木素、鹰嘴豆芽素A
Pueraria lobata(Willd.)Ohwi
isoflavones
pharmacological effects
puerarin
daidzein
genistein
biochanin A
