摘要
Wereport a base-promoted catalyst-free protocol for the highly regioselective hydroacylation of styrenes with hydrazones derived from naturally abundant aldehydes.This protocolgeneratedlinearketoneswith goodfunctional grouptolerance anda broadsubstrate scope under mild conditions.Mechanistic studies showed that the addition of hydrazone anion to a styrene double bond was the key step,different from previoushydroacylationpathways(viaorganometallic complexes or radical intermediates).
基金
from the National Natural Science Foundation of China(grant no.21971093)
the International Joint Research Centre for Green Catalysis and Synthesis(grant no.2016B01017),and the 111 project.
